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Citation: LIU Jian-Chao, HE Hong-Wu. Synthesis and Biological Activities of Thieno [2,3-b] pyridine Derivatives[J]. Chinese Journal of Applied Chemistry, ;2010, 27(10): 1161-1164. doi: 10.3724/SP.J.1095.2010.90876 shu

Synthesis and Biological Activities of Thieno [2,3-b] pyridine Derivatives

LIU Jian-Chao ^a,b, ,
HE Hong-Wu ^a

a. College of Chemistry, Central China Normal University, Wuhan 430079;
b. College of Chemistry and Chemical Engineering, Central South University, Changsha

Received Date: 24 December 2009
Revised Date: 2 April 2010

A facile synthetic method for thienopyridine derivatives was developed via the reaction of 2-aminothiophenes with acetoacetic ester and tin tetrachloride under heating.Four thienopyridine derivatives were obtained.The structures of the target compounds were determined by means of IR,¹H NMR,MS and elemental analysis.Preliminary biological activities of the four thienopyridine derivatives showed that most of them display high fungicidal activities and a certain extent of herbicidal activities as well.
- thieno[2,3-b]pyridine,
- acetoacetic ester,
- fungicidal activities,
- herbicidal activities
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