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Citation: SHI Xiao-Ning, WANG Jin-Xian. Microwave Irradiation Synthesis of 3,5-Diarylisoxazoles in Aqueous Solution[J]. Chinese Journal of Applied Chemistry, ;2010, 27(5): 539-543. doi: 10.3724/SP.J.1095.2010.90435 shu

Microwave Irradiation Synthesis of 3,5-Diarylisoxazoles in Aqueous Solution

SHI Xiao-Ning ^a, ,
WANG Jin-Xian ^b

a. School of Life Science and Chemistry, Tianshui Normal University, Tianshui 741000;
b. Institute of Chemistry, Department of Chemistry, Northwest Normal University, Lanzhou

Received Date: 1 July 2009
Revised Date: 11 August 2009

2,4,6-Triarylpyrylium salts were synthesized with aromatic aldehydes and aromatic ketones as starting materials.We succeeded in the conversion of these salts with hydroxylamine hydrochloride in water and synthesized the 3,5-diarylisoxazole derivatives under microwave irradiation.In comparison with literature method,the microwave approach shows the salient features of rapid reaction rates and significant energy saving,clean reaction conditions,enhancement in chemical yield,and nonuse of perchloric acid(70%),which will result in cost saving and minimize safety concerns in the organic laboratory.In addition,the use of aqueous reaction conditions results in simple,environmentally friendly procedures.This rapid and easy technique coupled with water medium may contribute to the dream of Green Technology.The optimum reaction conditions were selected(P=600 W,time=8 min,yield 83%) and twelve compounds were synthesized via this procedure.The structures of the products were confirmed by elemental analysis,MS and ¹H NMR spectroscopy.
- microwave irradiation,
- triarylpyrylium salt,
- hydroxylamine hydro-chloride,
- diarylisoxazole,
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