Citation:
HUANG Zhong-Jinga, YANG Run-Yunb, GUO Zhi-Yongb, SHE Zhi-Gangb, LIN Yong-Cheng. New Anthraquinone Derivative Produced by Cultivation of Mangrove Endophytic Fungus Fusarium sp. ZZF60 from the South China Sea[J]. Chinese Journal of Applied Chemistry,
;2010, 27(4): 394-397.
doi:
10.3724/SP.J.1095.2010.90377
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A new anthraquinone derivative,6,8-dimethoxy-1-methyl-2-(3-oxobutyl) anthrakunthone(1),together with five known compounds,7-hydroxy-3-(4-methoxyphenyl)-chromen-4-one(2),2,4-dihydroxy-6-[(1'E,3'E)-penta-1',3'-dienyl]-benzaldehyde(3),(E)-4hydroxycinnamic acid methyl ester(4),4-(4-hydroxyphenyl)-butan2-ol(5),and 4-hydroxybenzoic acid(6),were isolated from the marine mangrove endophytic fungus Fusarium sp.ZZF60 from the South China Sea.Their structures were elucidated by spectral data of IR,MS and NMR.In the preliminary bioassay,compound 1 showed cytotoxicity towards Hep2 and HepG2 with IC50 values of 16 μmol/L and 23 μmol/L,respectively.
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