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Citation: MA Zhong-Hua, ZHANG Jia-Yan, NIE Jin. Selective Synthesis of 2-Benzyl-4-chlorophenol Catalyzed by Zn(OTf)₂[J]. Chinese Journal of Applied Chemistry, ;2010, 27(3): 304-307. doi: 10.3724/SP.J.1095.2010.90271 shu

Selective Synthesis of 2-Benzyl-4-chlorophenol Catalyzed by Zn(OTf)₂

a. School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074;
b. Department of Chemistry, College of Basic Sciences, Huazhong Agricultural University, Wuhan 430074

Received Date: 14 April 2009
Revised Date: 26 July 2009

C-Benzylation of 4-chlorophenol(BCP) was selectively perpared via the catalysis of Zn(OTf)₂ under mild conditions with an excellent yield.The optimum reaction conditions included that the molar ratio of the reactants(4-chlorophol:benzyl chloride) was 1.2:1,5% Zn(OTf)₂(molar ratio),and 6 h agitation at 60℃ in nitromethane.The conversion of 4-chlorophenol and selectivity of BCP were >99% and 94%,respectively under the conditions.
- zinc(Ⅱ)trifluoromethnesulfonate,
- benzyl-chlorophenol,
- Friedel-Crafts alkylation,
- p-chlorophenol,
- benzyl chloride
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Selective Synthesis of 2-Benzyl-4-chlorophenol Catalyzed by Zn(OTf)2

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通讯作者: 陈斌, bchen63@163.com

Selective Synthesis of 2-Benzyl-4-chlorophenol Catalyzed by Zn(OTf)₂