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Citation: WEI Chu-Quan, LI Yong-Xiu, SUN Xiao-Fei. Synthesis of γ-Aminobutyric Acid Isothiocyanate Conjugated Norcantharidin and Substituted Anilin and Anticonvulsant Activity[J]. Chinese Journal of Applied Chemistry, ;2010, 27(3): 300-303. doi: 10.3724/SP.J.1095.2010.90243 shu

Synthesis of γ-Aminobutyric Acid Isothiocyanate Conjugated Norcantharidin and Substituted Anilin and Anticonvulsant Activity

School of Pharmacy, Medical College of Soochow University, Suzhou 215123

Received Date: 7 April 2009
Revised Date: 20 July 2009

In order to find new anticonvulsant compounds,we designed and synthesized eleven target compounds of γ-aminobutyric acid isothiocyanate conjugated norcantharidin and substituted anilin.The structures were identified by IR,¹H NMR and HR-MS.Preliminary test of anticonvulsant activity shows that compounds Ⅱ₂,Ⅱ₃ and Ⅱ₈ have appreciable antiepileptic activity.
- norcantharidin,
- anticonvulsant,
- synthesis,
- γ-aminobutyric acid isothiocyanate conjugated norcantharidin
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