Citation: JIANG Tao, DU Lianyun, ZHU Shuang, WANG Huan, ZHAN Yu, YU Ping, ZHANG Zhe, WANG Enpeng, CHEN Changbao. Rapid Determination of Three Components in Cosmetics by Using Direct Real-time Analysis Ionization Mass Spectrometry[J]. Chinese Journal of Applied Chemistry, ;2020, 37(11): 1333-1339. doi: 10.11944/j.issn.1000-0518.2020.11.200202 shu

Rapid Determination of Three Components in Cosmetics by Using Direct Real-time Analysis Ionization Mass Spectrometry

Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, China

Corresponding author: WANG Enpeng, robbinwang@163.com CHEN Changbao, ccb@126.com
Received Date: 3 July 2020
Revised Date: 5 August 2020
Accepted Date: 4 September 2020

Fund Project: Jilin Province Science and Technology Development Plan Project 20190201297JCthe National Key Research and Development prijects 2019YFC1710704Jilin Province Science and Technology Development Plan Project 20200504003YYhe Major Special Project of Science and the Technology Innovation of Changchun Science and Technology Bureau 17YJ008Supported by the National Key Research and Development prijects(No.2019YFC1710704), Jilin Province Science and Technology Development Plan Project(No.20200404042YY, No.20190201297JC, No.20190304099YY, No.20200504003YY), the Major Special Project of Science and the Technology Innovation of Changchun Science and Technology Bureau(No.17YJ008) and Jiayi Biological R & D Centre (Suzhou Industrial Park) Co., LTDJilin Province Science and Technology Development Plan Project 20200404042YYJilin Province Science and Technology Development Plan Project 20190304099YY

Figures(3)

A rapid method for the determination of the contraindicated component urocanic acid(URA), approved sunscreens 2-ethylhexyl 4-methoxycinnamate(EHMC) and butyl-methoxydibenzoylmethane(B-MDM) in cosmetics were developed using direct analysis in real time (DART) of ion sources combined with four-pole flight mass spectroscopy. For qualitative analysis by positive ions, the Full MS/Targeted MS² mode is applied to obtain the mass spectrum and cosmetics can be directly analyzed in the ionized area. For quantitative analysis, DART parameters are systematically optimized to achieve the best detection performance and the module sampler is used for automatic sampling. The linear range of three kinds of components is 25~1000 mg/L in the calibration curve with a good linear relationship (r>0.99). The lowest limit of detection (S/N=3) is 7.5 mg/L and the minimum quantitative limit (S/N=10) is 25 mg/L. The method recovery is 96.7%~109.2% and the precision RSD (n=6) is 3.59%~11.23%. The method is simple, rapid, efficient and environmentally-friend. It can be widely used in the rapid screening and quantitative detection of banned additives in cosmetics.
- direct analysis in real time mass spectrometry,
- sunscreens,
- urocanic acid,
- 2-ethylhexyl 4-methoxycinnamate,
- butyl-methoxydibenzoylmethane
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沈阳化工大学材料科学与工程学院沈阳 110142