Citation: ZHANG Baohua, SHI Lanxiang. One-Pot Synthesis of Aryl/Heteroaryl Aminomethylene Bisphosphonates[J]. Chinese Journal of Applied Chemistry, ;2020, 37(8): 877-882. doi: 10.11944/j.issn.1000-0518.2020.08.200056 shu

One-Pot Synthesis of Aryl/Heteroaryl Aminomethylene Bisphosphonates

ZHANG Baohua ,
SHI Lanxiang ^,

College of Chemical Engineering, Shijiazhuang University, Shijiazhaung, Hebei 050035, China

Corresponding author: SHI Lanxiang, kedashilanxiang@163.com
Received Date: 28 February 2020
Revised Date: 3 April 2020
Accepted Date: 28 April 2020

Fund Project: the Hebei Province Science and Technology Support Project 18271404DSupported by the Hebei Province Science and Technology Support Project(No.18271404D)

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A number of aryl/heteroaryl aminomethylene bisphosphonates were synthesized by one-pot reaction of diverse aryl/heteroaryl amines with diethyl phosphite and triethyl orthoformate in the presence of I₂ under solvent free conditions. The product yields are 96%~99%. When the molar fraction of I₂ is 5%, the product yield is the highest. The procedure is simple and the substrate scope is large. I₂ is safe and very efficient as the catalyst.
- aryl/heteroaryl aminomethylene bisphosphonates,
- I₂,
- one-pot synthesis,
- solvent free
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