Citation: LI Weijia, MA Zhifang, XIN Zhirong, SHI Qiang. Application of Fe-Co Two-Dimension-Layered Double Hydroxide in Synergetic Therapy of Cancer[J]. Chinese Journal of Applied Chemistry, ;2020, 37(6): 627-634. doi: 10.11944/j.issn.1000-0518.2020.06.190322 shu

Application of Fe-Co Two-Dimension-Layered Double Hydroxide in Synergetic Therapy of Cancer

LI Weijia ^1,2 ,
MA Zhifang ^2,, ,
XIN Zhirong ^1,, ,
SHI Qiang ²

a.
College of Chemistry and Chemical Engineering, Yantai University, Yantai, Shandong 264600, China
b.
State Key Laboratory of Polymer Physics and Chemistty, Changchun Institute of Applied Chemistry, Chinese Acdemy of Sciences, Changchun 130022, China

Corresponding author: MA Zhifang, zfma@ciac.ac.cn XIN Zhirong, Xinzhirong2012@126.com
Received Date: 28 November 2019
Revised Date: 4 January 2020
Accepted Date: 25 February 2020

Fund Project: the Open Research Fund of State Key Laboratory of Polymer Physics and Chemistry, CIAC, CAS 201620the National Natural Science Foundation of China 51573186the Open Research Fund of State Key Laboratory of Polymer Physics and Chemistry, CIAC, CAS 201628the National Key Research and Development Program of China 2016YFC1100402the Natural Science Foundation of Shandong Province ZR2019MEM008Supported by the National Key Research and Development Program of China(No.2016YFC1100402), the National Natural Science Foundation of China(No.51573186, No.51973222), the Open Research Fund of State Key Laboratory of Polymer Physics and Chemistry, CIAC, CAS(No.201620, No.201628), and the Natural Science Foundation of Shandong Province(No.ZR2019MEM008)the National Natural Science Foundation of China 51973222

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Photon therapy is a new selective cancer treatment technology which has been developed rapidly in recent years. It has the advantages of small trauma, good selectivity, low toxicity and no drug resistance. In this paper, we used hydrothermal synthesis method to prepare a new kind of layered Co-Fe double hydroxide nanosheet (Co-Fe-LDH) which has the characteristics of large specific surface area, high stability and good biocompatibility and is used to load photosensitizer IR783 (LDH-IR783) to realize the photothermal/photodynamic cooperative phototherapy of cancer under the stimulation of near-infrared laser. We characterized the composition, morphology, optical property, reactive oxygen species (ROS) generation and heat release of LDH-IR783 and tested its anticancer activity at the cellular and in vivo levels. The results indicate that the nanocomposite has a stable structure, high IR783 loading efficiency and good dispersibility, exhibits excellent photothermal/photodynamic effects under near-infrared light irradiation through producing considerable ROS and releasing heat rapidly to induce severe phototoxicity to cancer cells. Both in vitro and in vivo experiments display that the nanocomposite can effectively induce apoptosis of HeLa cells and significantly inhibit the growth of solid tumors without obvious side effects and damage to normal tissue. The preliminary results will provide new ideas for the design and application of photo-thermal/photodynamic synergistic drugs.
- cancer,
- near-infrared laser,
- photothermal therapy,
- photodynamic thrapy,
- layed double hydroxide
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