Citation: CHEN Shaodong, WANG Xiaojuan, LI Duanxiu, WANG Zhaoxi, ZHANG Hailu. Preparation and Characterization of Etodolac-Piperazine Salt[J]. Chinese Journal of Applied Chemistry, ;2020, 37(1): 103-108. doi: 10.11944/j.issn.1000-0518.2020.01.190185 shu

Preparation and Characterization of Etodolac-Piperazine Salt

a.
College of Science, Shanghai University, Shanghai 200444, China
b.
Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, Jiangsu 215123, China

Corresponding author: ZHANG Hailu, hlzhang2008@sinano.ac.cn
Received Date: 3 July 2019
Revised Date: 4 September 2019
Accepted Date: 12 October 2019

Fund Project: the Youth Innovation Promotion Association of CAS 2012242Supported by the National Natural Science Foundation of China (No. 21874148), the Youth Innovation Promotion Association of CAS (No. 2012242), and the China Postdoctoral Science Foundation and the CAS Jointly Funded Outstanding Postdoctoral Project (No. 2017LH045)the National Natural Science Foundation of China 21874148the China Postdoctoral Science Foundation and the CAS Jointly Funded Outstanding Postdoctoral Project 2017LH045

Figures(7)

An organic salt of etodolac and piperazine was prepared and the crystal structure was obtained. Structural analysis indicated that a hydrogen proton transferred from etodolac carboxyl group to piperazine nitrogen atom. The N-H…O hydrogen bond was the main intermolecular interaction to maintain structural stability. The intrinsic dissolution rate and equilibrium solubility of the newly synthesized salt were increased by 2.1 times and 4.8 times, respectively, compared with the original etodolac. In addition, the newly synthesized salt has good hydration stability without phase transition for 4 weeks at 25℃ and 95% relative humidity. As the first organic salt of etodolac, the etodolac-piperazine salt is a promising new solid form of etodolac.
- etodolac,
- organic salt,
- structure analysis,
- thermal analysis,
- hydration stability,
- solubility
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沈阳化工大学材料科学与工程学院沈阳 110142