Citation: LIU Xuewen, TANG Yucai. A Luminescent Probe Based on Ruthenium(Ⅱ) Complex for the Detection of Cysteine and Homocysteine[J]. Chinese Journal of Applied Chemistry, ;2019, 36(12): 1456-1461. doi: 10.11944/j.issn.1000-0518.2019.12.190099 shu

A Luminescent Probe Based on Ruthenium(Ⅱ) Complex for the Detection of Cysteine and Homocysteine

LIU Xuewen ^a,b,, ,
TANG Yucai ^a,b

a.
College of Chemistry and Material Engineering, Hunan University of Arts and Science, Changde, Hunan 415000, China
b.
State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China

Corresponding author: LIU Xuewen, liuxuewen050@sina.com
Received Date: 11 April 2019
Revised Date: 29 May 2019
Accepted Date: 11 July 2019

Fund Project: Supported by the Research Foundation of Education Bureau of Hunan Province(No.16A145), and the State Key Laboratory of Coordination Chemistry(No.SKLCC1920)the Research Foundation of Education Bureau of Hunan Province 16A145the State Key Laboratory of Coordination Chemistry SKLCC1920

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A new turn-on type of luminescence probe based on ruthenium(Ⅱ) complex, [Ru(5-CHO-phen)₃]²⁺(5-CHO-phen=1, 10-phenanthroline-5-carbaldehyde), has been designed and synthesized. The probe displayed good sensitivity and selectivity toward cysteine (Cys) and homocysteine (Hcy). Enhanced luminescence intensity of this probe displays a good linear relationship in the concentration range of 5 to 35 μmol/L for Cys and Hcy. The detection limit is 0.60 μmol/L and 0.78 μmol/L for Cys and Hcy, respectively. The proposed approach provides a useful method by using luminescence probe based on ruthenoium(Ⅱ) complex for the quantitative detection of various biological molecules.
- cysteine,
- homocysteine,
- ruthenium(Ⅱ) complex,
- luminescent probe
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