Citation: SUN Fengmei, HAN Qiong, ZHAO Panxiang, WANG Jia, RUI Jiayi, XU Jiming. Synthesis and 1, 1-Diphenyl-2-Picrylhydrazyl Radical Quenching Activity of Salicylaldehyde Schiff Bases Containing Morpholine Fragments[J]. Chinese Journal of Applied Chemistry, ;2019, 36(5): 524-531. doi: 10.11944/j.issn.1000-0518.2019.05.180296 shu

Synthesis and 1, 1-Diphenyl-2-Picrylhydrazyl Radical Quenching Activity of Salicylaldehyde Schiff Bases Containing Morpholine Fragments

School of Chemistry and Chemical Engineering, Huaiyin Normal University, Huai'an, Jiangsu 223300, China

Corresponding author: SUN Fengmei, sfmmm1219@126.com
Received Date: 7 September 2018
Revised Date: 26 November 2018
Accepted Date: 17 December 2018

Fund Project: Supported by the Jiangsu Province College Students′ Practice and Innovation Training Program(No.201810323007Z)the Jiangsu Province College Students′ Practice and Innovation Training Program 201810323007Z

Figures(2)

Fourteen kinds of salicylaldehyde Schiff bases containing morpholinyl fragments are synthesized by the condensation reaction of 3-fluoro-4-morpholiniline and substituted salicylate and confirmed by nuclear magnetic resonance spectroscopy(NMR), Fourier transform infrared spectrometer(FTIR), liquid chromatography-mass spectrometer(LC-MS) and element analysis. The 1, 1-diphenyl-2-picrylhydrazyl(DPPH) radical quenching activities of these Schiff bases are also studied. The results show that all compounds show certain quenching activity of DPPH radicals at concentrations of 0.02 to 0.10 g/L. Among them, the compounds Ⅰd and Ⅰf show excellent properties. The activity of compound Ⅰd is between 30% and 55%, and the activity of compound Ⅰf is more than 50%. With the increase of the concentration of compounds Ⅰd, Ⅰh, Ⅰj and Ⅰn, the DPPH radical quenching activities increase.
- 3-fluoro-4-morpholinine,
- Schiff base,
- 1, 1-diphenyl-2-picrylhydrazyl radical
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