Citation: BAO Jinping, FAN Sufang, YANG Guoyu, WANG Zhimin, WANG Ying, LIU Xiaohua, XU Cuilian. Synthesis and Antifungal Activities of Chitosan Oligosaccharide Thiosemicarbazone Schiff Base Cu(Ⅱ) Complex[J]. Chinese Journal of Applied Chemistry, ;2019, 36(5): 500-508. doi: 10.11944/j.issn.1000-0518.2019.05.180284 shu

Synthesis and Antifungal Activities of Chitosan Oligosaccharide Thiosemicarbazone Schiff Base Cu(Ⅱ) Complex

College of Sciences, Henan Agricultural University, Zhengzhou 450002, China

Corresponding author: YANG Guoyu, ygy1096@sina.com XU Cuilian, xucuilian666@126.com
Received Date: 3 September 2018
Revised Date: 7 December 2018
Accepted Date: 3 January 2019

Fund Project: the Science and Technology Tackling Key Project of Henan Province 1521021100700the Science and Technology Tackling Key Project of Henan Province 112101110200National Undergraduate Training Program for Innovation and Entrepreneurship 201610466022Supported by the Science and Technology Tackling Key Project of Henan Province(No.1521021100700, No.112101110200), Project of Subsidized Youth Backbone Teachers in Henan Higher Education Institutions(No.2014GGJS-083), National Undergraduate Training Program for Innovation and Entrepreneurship(No.201610466022)Project of Subsidized Youth Backbone Teachers in Henan Higher Education Institutions 2014GGJS-083

Figures(8)

Chitosan oligosaccharide thiosemicarbazide was prepared in one-pot. Then chitosan oligosaccharide thiosemicarbazone was synthesized by the reaction of chitosan thiosemicarbazide with 2-pyridinecarboxaldehyde. Chitosan oligosaccharide thiosemicarbazone Cu(Ⅱ) complex was thus obtained by the reaction of chitosan thiosemicarbazide with Cu(Ⅱ) salt. The structure of the synthesized compounds was characterized by infrared(IR) spectroscopy, ultraviolet-visible(UV-Vis) spectroscopy, nuclear magnetic resonance(NMR), inductively coupled plasma(ICP), and thermogravimetry-differential thermal analysis(TG-DTA). The antifungal behaviors of chitosan oligosaccharide and its derivatives against three crop-threatening pathogenic fungi:Phytophthora capsici (P.capsici), Phytophthora nicotianae (P.nicotianae), Fusarium graminearum (F.graminearum) were investigated by mycelial growth rate method in vitro. The results show that the inhibitory index of chitosan thiosemicarbazone Cu(Ⅱ) complex against P.capsici, P.nicotianae, F.graminearum is 74.19%, 56.60%, 66.60%, respectively, and is higher than those observed with chitosan.
- chitosan oligosaccharide,
- thiosemicarbazide,
- Cu(Ⅱ) complex,
- antifungal activity
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