Citation: GONG Tao, HUANG Yu, GUO Guoying, SU Dan, LIANG Wenting, DONG Chuan. Linear Maltodextrin Polymer Functionalized Fe₃O₄ Magnetic Nanoparticles as Drug Carriers[J]. Chinese Journal of Applied Chemistry, ;2019, 36(2): 161-169. doi: 10.11944/j.issn.1000-0518.2019.02.180204 shu

Linear Maltodextrin Polymer Functionalized Fe₃O₄ Magnetic Nanoparticles as Drug Carriers

GONG Tao ^a,b ,
HUANG Yu ^b ,
GUO Guoying ^a ,
SU Dan ^a ,
LIANG Wenting ^b,, ,
DONG Chuan ^b,,

a.
Department of Biochemistry and Molecular Biology, Shanxi Medical University, Taiyuan 030001, China
b.
School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China

Corresponding author: LIANG Wenting, liangwt@sxu.edu.cn DONG Chuan, dc@sxu.edu.cn
Received Date: 4 June 2018
Revised Date: 6 July 2018
Accepted Date: 15 August 2018

Fund Project: Supported by the National Natural Science Foundation of China(No.21402110, No.21575084), the Hundred Talent Program of Shanxi Provincethe National Natural Science Foundation of China 21575084the National Natural Science Foundation of China 21402110

Figures(9)

Linear maltodextrin polymer modified magnetic nanoparticles(LM-SP-MNPs) were prepared by chemical co-precipitation. The structure and morphology of LM-SP-MNPs were characterized by Fourier transform infrared spectroscopy, transmission electron microscopy and thermogravimetric analysis. The loading and release behaviors of LM-SP-MNPs as drug carrier were evaluated by fluorescence spectroscopy using doxorubicin(DOX) as a model drug. The pH effects on LM-SP-MNPs for drug releasing were investigated. Under the optimal pH conditions, the maximum loading of DOX into LM-SP-MNPs is 357.1 mg/g, and the loading behavior follows Freundlich adsorption balance equations with multilayer adsorption. Furthermore, the release ability of DOX@LM-SP-MNPs is more efficient under acid solution than that under natural solution at 37℃ in vitro. Accumulated release efficiency of DOX in 7 h is 26.9% at pH=5.3. In addition, the MTT assays show that LM-SP-MNPs have an excellent biocompatibility, and the DOX@LM-SP-MNPs decrease the relative cellular viability of HepG2 cells evidently.
- Linear maltodextrin polymer,
- Fe₃O₄ magnetic nanoparticle,
- doxorubicin,
- drug carrier
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Linear Maltodextrin Polymer Functionalized Fe₃O₄ Magnetic Nanoparticles as Drug Carriers