Citation: WANG He, LUO Jing, LI Xiaojie, SHI Dongjian, CHEN Mingqing. Efficient Preparation of Polydopamine Nanoparticles by Precipitation[J]. Chinese Journal of Applied Chemistry, ;2019, 36(2): 155-160. doi: 10.11944/j.issn.1000-0518.2019.02.180150 shu

Efficient Preparation of Polydopamine Nanoparticles by Precipitation

Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi, Jiangsu 214122, China

Corresponding author: LI Xiaojie, xjli@jiangnan.edu.cn
Received Date: 3 May 2018
Revised Date: 16 May 2018
Accepted Date: 2 July 2018

Fund Project: the Open Research Fund of Key Laboratory of Synthetic and Biological Colloids(Jiangnan University), Ministry of Education JDSJ2016-06the Fundamental Research Funds for the Central Universities JUSRP115A07the Jiangsu Planned Projects for Postdoctoral Research Funds 1601237CSupported by the Fundamental Research Funds for the Central Universities(No.JUSRP115A07), the Jiangsu Planned Projects for Postdoctoral Research Funds(No.1601237C), the Open Research Fund of Key Laboratory of Synthetic and Biological Colloids(Jiangnan University), Ministry of Education(No.JDSJ2016-06)

Figures(7)

In order to obtain dispersive and stable polydopamine nanoparticles, an aqueous dispersion of polydopamine nanoparticles was efficiently prepared using the "precipitation-redispersion" method. First, polydopamine nanoparticles dispersed in water/ethanol were prepared by a solution oxidation method, and then acetone was added to the dispersion to flocculate the polydopamine nanoparticles. The precipitate was collected, rinsed with acetone and dried, and then redispersed in water to obtain a purified aqueous dispersion of polydopamine nanoparticles. The polydopamine nanoparticles obtained by the acetone precipitation method are regular in shape with good dispersibility. The particle size distribution is about 250 nm, and has good storage stability and photothermal properties in water. Compared with conventional ultracentrifugation purification method, the yield increases by 57.4%. This method is essential for further applications in drug delivery and photothermal therapy/>
- polydopamine nanoparticles,
- precipitation method,
- purification
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