Citation: LIN Chen, LIN Xiaoyan, ZHANG Peng, XU Yiwen, XU Jianhua, KE Fang. Copper-catalyzed Microwave-Assisted Synthesis of N, N-Dimethyl-2-benzoxazolamine Derivatives[J]. Chinese Journal of Applied Chemistry, ;2019, 36(2): 182-187. doi: 10.11944/j.issn.1000-0518.2019.02.180094 shu

Copper-catalyzed Microwave-Assisted Synthesis of N, N-Dimethyl-2-benzoxazolamine Derivatives

LIN Chen ^a ,
LIN Xiaoyan ^a ,
ZHANG Peng ^a ,
XU Yiwen ^a ,
XU Jianhua ^a,b ,
KE Fang ^a,b,,

a.
Department of Pharmacy, Fujian Medical University, Fuzhou 350004, China
b.
Institute of Materia Medica, Fujian Medical University, Fuzhou 350004, China

Corresponding author: KE Fang, kefang612@163.com
Received Date: 30 March 2018
Revised Date: 8 May 2018
Accepted Date: 8 June 2018

Fund Project: the Department of Fujian Province Natural Science and Technology Foundation 2017J01820the Department of Fujian Province Natural Science and Technology Foundation 2016J01372the Fund of Fujian Medical University 2015MP008Supported by the Department of Fujian Province Natural Science and Technology Foundation(No.2016J01686, No.2016J01372, No.2016Y9051, No.2017J01820), the Fund of Fujian Medical University(No.2015MP008)the Department of Fujian Province Natural Science and Technology Foundation 2016J01686the Department of Fujian Province Natural Science and Technology Foundation 2016Y9051

Figures(1)

Microwave-assisted one-pot synthesis of a variety of N, N-dimethyl-2-benzoxazolamine derivatives were achieved by the cascade reaction of substituted 2-iodoanilines with dimethylcarbamothioic chloride in pyridine in the presence of CuI at 100℃ with moderate to good yields(up to 90%).
- microwave-assisted synthesis,
- N, N-dimethyl-2-benzoxazolamines,
- 2-iodoanilines
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沈阳化工大学材料科学与工程学院沈阳 110142