Citation: WANG Yupeng, ZHOU Dongfang, CHENG Yanxiang, HUANG Yubin. Hemoglobin/Photosensitizer Compound Drug System for Photodynamic Therapy[J]. Chinese Journal of Applied Chemistry, ;2018, 35(12): 1442-1448. doi: 10.11944/j.issn.1000-0518.2018.12.180102 shu

Hemoglobin/Photosensitizer Compound Drug System for Photodynamic Therapy

a.
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
b.
Graduate School of the Chinese Academy of Sciences, Beijing 100039, China

Corresponding author: HUANG Yubin, ybhuang@ciac.ac.cn
Received Date: 8 April 2018
Revised Date: 23 April 2018
Accepted Date: 6 June 2018

Fund Project: the National Natural Science Foundation of China 51673188Supported by the National Natural Science Foundation of China(No.51673188)

Figures(5)

In this paper, the loading of both hemoglobin and photosensitizer drug heptamethine cyanine fluorescent small molecule:11-chloro-1, 1'-di-n-propyl-3, 3, 3', 3'-tetramethyl-10, 12-trimethylene quinone three-carbon cyanine iodide salt(IR780) was achieved by the isoelectric point method. The effect of the combined treatment of hemoglobin oxygen therapy and photodynamic therapy was studied. The morphology and stability of the hemoglobin/IR780 complex drug carrier were studied by transmission electron microscopy and dynamic light scattering, proving that the drug carrier maintains good stability under physiological conditions. The reactive oxygen species(ROS) detection of the drug in the solution and cell confirmed that the oxygen supply of hemoglobin could promote the production of ROS effectively. Meanwhile, it was also confirmed that the hemoglobin/IR780 complex drug carrier was more efficient to kill tumor cells than the single component IR780 drug in cell cytotoxicity experiments.
- hemoglobin,
- photodynamic therapy,
- oxygen therapy
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