Citation: XU Kunlun, CAO Zubin, QIAO Haiyan, HAN Dongyun, SHI Weiwei. CuI/2, 2'-Bipyridine/2, 2, 6, 6-Tetramethylpiperidinooxy Catalytic Oxidation Process of Alcohol to Nitrile[J]. Chinese Journal of Applied Chemistry, ;2018, 35(11): 1335-1341. doi: 10.11944/j.issn.1000-0518.2018.11.170446 shu

CuI/2, 2'-Bipyridine/2, 2, 6, 6-Tetramethylpiperidinooxy Catalytic Oxidation Process of Alcohol to Nitrile

Liaoning Shihua University, College of Chemistry, Chemical Engineering and Environmental Engineering, Fushun, Liaoning 113001, China

Corresponding author: CAO Zubin, caozubin974@163.com
Received Date: 11 December 2017
Revised Date: 25 January 2018
Accepted Date: 9 February 2018

Fund Project: Supported by the National Natural Science Foundation of China(No.21276253), Research Foundation of Liaoning Shihua University(No.2016XJJ-017)Research Foundation of Liaoning Shihua University 2016XJJ-017the National Natural Science Foundation of China 21276253

Figures(4)

CuI/Bipy (2, 2'-bipyridine)/TEMPO (2, 2, 6, 6-Tetramethylpiperidinooxy) catalytic oxidation process was optimized for nitriles synthesis using alcohols as starting material with aqueous ammonia as nitrogen source and molecular oxygen as the oxidant in a pressurized reactor. The effect of copper salts, catalyst loading, solvent, reaction temperature and reaction time were studied using benzyl alcohol as a model substrate. It is shown that low catalyst loading (1% molar fraction for aromatic alcohols, 5% molar fraction for aliphatic alcohols) and short reaction time (8 hours) are required for oxidizing both aromatic and aliphatic alcohols to their corresponding nitriles over 90% conversion rate and 90% yield under 40×10⁵ Pa presure of O₂ (8% volume fraction)-N₂ gas mixture at 120℃.
- alcohols,
- nitriles,
- catalytic oxidation,
- high pressure reactor
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