Citation: GUI Shuya, XIONG Hao, LIN Zhi, XIA Linya, ZHONG Qisheng, LI Dongfeng, HOU Ruibin, XIA Yan. Synthesis and Primary Antitumor Proliferation of p-Adamantanylcinnamides[J]. Chinese Journal of Applied Chemistry, ;2018, 35(4): 420-425. doi: 10.11944/j.issn.1000-0518.2018.04.170147 shu

Synthesis and Primary Antitumor Proliferation of p-Adamantanylcinnamides

College of Chemistry and Life Science, Changchun University of Technology, Changchun 130012, China

Corresponding author: HOU Ruibin, hrb1018@163.com XIA Yan, xiayan@ccut.edu.cn
Received Date: 10 May 2017
Revised Date: 12 May 2017
Accepted Date: 22 June 2017

Fund Project: Supported by the National Natural Science Foundation of China(No.21502008), Department of Jilin Province Key Scientific Research Project(No.20110333)Department of Jilin Province Key Scientific Research Project 20110333the National Natural Science Foundation of China 21502008

Figures(1)

Three aniline p-adamantanylcinnamides(8a~8c) were designed and synthesized from cross coupling of 1-bromoadamantane with toluene followed by oxidation, homologation and amidation. The inhibitory assays of these compounds against human hepatocellular carcinoma cell SMMC7721, breast cancer cell MCF-7, cervical cancer cell Hela and lung cancer cell A549 by MTS method showed that compound 8c exhibited good antitumor activity against human hepatoma cells(IC₅₀=1.6 μmol/L or 0.73 mg/L) compared with doxorubicin(0.44 mg/L). This indicates that aniline p-adamantanylcinnamide is a good template for the development of anti-tumor drugs. The antitumor activity, cellular targets and the mode of action of aniline p-adamantanylcinnamide derivatives will be further studied.
- adamantane styrene,
- synthesis,
- antitumor activity,
- MTS
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沈阳化工大学材料科学与工程学院沈阳 110142