Citation: XU Yulin, LIU Chunrong. Research Progress on Fluorescence Detection of Methionine Sulfoxide/Methionine Sulfoxide Reductases[J]. Chinese Journal of Applied Chemistry, ;2018, 35(1): 21-27. doi: 10.11944/j.issn.1000-0518.2018.01.170338 shu

Research Progress on Fluorescence Detection of Methionine Sulfoxide/Methionine Sulfoxide Reductases

XU Yulin ,
LIU Chunrong ^,

Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, and School of Chemistry, Central China Normal University, Wuhan 430079, China

Corresponding author: LIU Chunrong, liucr@mail.ccnu.edu.cn
Received Date: 18 September 2017
Revised Date: 9 October 2017
Accepted Date: 11 October 2017

Fund Project: the Nationan Natural Science Foundation of China 21502064Supported by the Nationan Natural Science Foundation of China(No.21502064)

Figures(4)

As a new type of protein redox-based post-translational modification acting as a molecular switch for the modulation of protein functions, the protein methionine sulfoxidation not only acts as a biomarker of cellular oxidative stress, but also regulates redox signaling transductions, which is thus closely related to many diseases, especially neurodegenerative diseases. In many organisms, the only molecule known to reduce the methionine sulfoxide is methionine sulfoxide reductases(Msrs), which can repair the oxidation damage and recover the function of protein thus play important roles in cellular redox balance regulations. In this article, we will first discuss the structure and catalytic mechanism of protein methionine sulfoxide(MetO) and Msrs, then review the recently developed fluorescent probes for MetO/Msrs type A(MsrA), and give a brief prospect at the last.
- methionine sulfoxide,
- oxidative stress,
- neurodegeneration diseases,
- methionine sulfoxide reductase,
- fluorescent probe
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