Citation: CHEN Minggui, HUA Xuewen, Wei WEI, ZHANG Dongkai, LIU Ming, WU Changchun, ZHOU Sha, LI Yuxin, WANG Baolei, ZHOU Sha, LI Zhengming. Design, Synthesis and Fungicidal Bioactivity of 1, 2, 4-Triazoles or Thiadiazoles Containing a Benzenesulfonamide Moiety[J]. Chinese Journal of Applied Chemistry, ;2017, 34(10): 1161-1171. doi: 10.11944/j.issn.1000-0518.2017.10.170163 shu

Design, Synthesis and Fungicidal Bioactivity of 1, 2, 4-Triazoles or Thiadiazoles Containing a Benzenesulfonamide Moiety

CHEN Minggui ^a ,
HUA Xuewen ^b ,
Wei WEI ^a ,
ZHANG Dongkai ^a ,
LIU Ming ^a ,
WU Changchun ^a ,
ZHOU Sha ^a ,
LI Yuxin ^a ,
WANG Baolei ^a ,
ZHOU Sha ^a ,
LI Zhengming ^a,,

a.
State Key Laboratory of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering(Tianjin), Nankai University, Tianjin 300071, China
b.
College of Agriculture, Liaocheng University, Liaocheng, Shandong 252000, China

Corresponding author: LI Zhengming, nkzml@vip.163.com
Received Date: 18 May 2017
Revised Date: 14 June 2017
Accepted Date: 28 June 2017

Fund Project: Supported by the National Natural Science Foundation of China(No.21272129)the National Natural Science Foundation of China 21272129

Figures(4)

In order to explore efficient, low toxic and eco-friendly fungicides, a series of 1, 2, 4-triazole and thiadiazole derivatives containing benzenesulfonamide moieties was designed and synthesized. Their chemical structures were confirmed by nuclear magnetic resonance spectroscopy(NMR), mass spectrometry and elemental analysis. Preliminary fungicidal bioassay in vitro was carried out against seven plant pathogenic fungi and the results showed that compounds 10 exhibited moderate fungicidal activities, especially 10a, 10g and 10n demonstrated similar high inhibition rate against Fusarium moniliforme in comparison with commercial Azoxystrobin.
- triazole,
- thiadiazole,
- benzenesulfonamide,
- fungicidal activity
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