Citation: WANG Tong, LIU Shi, ZHANG Xiuying. Application of Cisplatin-loaded Thermosensitive Hydrogel in Local Chemotherapy of Cervical Cancer in Mice[J]. Chinese Journal of Applied Chemistry, ;2017, 34(10): 1127-1133. doi: 10.11944/j.issn.1000-0518.2017.10.170049 shu

Application of Cisplatin-loaded Thermosensitive Hydrogel in Local Chemotherapy of Cervical Cancer in Mice

WANG Tong ^a,c ,
LIU Shi ^b,, ,
ZHANG Xiuying ^a,,

a.
Veterinary Pharmacology and Toxicology Laboratory, College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China
b.
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
c.
DaCheng Farm(Liaoning) Limited Company, Shenyang 110000, China

Corresponding author: LIU Shi, liushil@126.com ZHANG Xiuying, paperpersonal@163.com
Received Date: 28 February 2017
Revised Date: 16 March 2017
Accepted Date: 2 May 2017

Fund Project: the National Natural Science Foundation of China 81602715Supported by the National Natural Science Foundation of China(No.81602715)

Figures(4)

To explore the application of cisplatin-loaded thermosensitive hydrogel in the treatment of the cervical cancer in mice, cisplatin-loaded poloxamer thermosensitive hydrogel was prepared and characterized. The mouse uterine cervical cancer cell line U14 was injected into submucosa nearby the cervix in female mice. Drug-loaded hydrogel was infused into the vagina of tumor-bearing mice and the inhibitory effect was evaluated. The results show that the tumor inhibition rate is as high as 63.1% by vaginal administration of cisplatin-loaded poloxamer hydrogel, which presents a new formulation for the local drug delivery via vagina against cervical cancer.
- cisplatin,
- thermosensitive hydrogel,
- cervical cancer,
- poloxamer
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