Citation: LEI Jiao, LUO Li, FU Weiwei, ZHOU Wenjun. Microwave-Assisted Synthesis of Benzoxazoles in Glycerol[J]. Chinese Journal of Applied Chemistry, ;2017, 34(3): 324-329. doi: 10.11944/j.issn.1000-0518.2017.03.160243 shu

Microwave-Assisted Synthesis of Benzoxazoles in Glycerol

LEI Jiao ^a ,
LUO Li ^a ,
FU Weiwei ^a ,
ZHOU Wenjun ^a,b,*,,

a.
College of Chemistry and Chemical Engineering, Neijiang, Sichuan 641112, China
b.
Key Laboratory of Fruit Waste Treatment and Resource Recycling of the Sichuan Provincial College, Neijiang, Sichuan 641112, China

Corresponding author: ZHOU Wenjun, chemzhwj@126.com
Received Date: 13 June 2016
Revised Date: 27 July 2016
Accepted Date: 15 August 2016

Fund Project: Supported by the Sichuan Province Education Office Fostering Projects No.15Z0026the Startup Foundation of Ph. D. Scientific Research of Neijiang Normal University No.2012B05

Figures(1)

Benzoxazole derivatives are well known for their applications in medicinal, industrial and synthetic organic chemistry. Numerous effects has been focused on developing efficient methods for the synthesis of it. The benzoxazole derivatives was synthesised by condensation of 2-aminophenol and benzaldehyde in presence of glycerol under focused microwave-irradiation conditions. Reaction conditions:2-aminothiophenol(1.0 mmol), benzaldehyde(1.0 mmol), glycerol(2 mL), irradiating under focused microwave for several minutes at 20 W and 110℃. The corresponding products was obtained in 80% to 91% yield. The present method has the advantages of mild conditions, green solvent, simple operation, easily available reaction substrates, and excellent product yields, which make it a useful and important supplement to the existing methods.
- benzoxazole,
- glycerol,
- aminophenol,
- aromatic aldehydes
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