Citation: ZHANG Fuxing, KUANG Daizhi, LI Xuanjie, FENG Yonglan, WANG Jianqiu, YU Jiangxi, JIANG Wujiu, ZHU Xiaoming. Synthesis, Structures and Properties of Tris (o-methylbenzyl) tin Thiosalicylate and Di (m-fluorobenzyl) tin Thiosalicylate[J]. Chinese Journal of Applied Chemistry, ;2017, 34(2): 163-171. doi: 10.11944/j.issn.1000-0518.2017.02.160183 shu

Synthesis, Structures and Properties of Tris (o-methylbenzyl) tin Thiosalicylate and Di (m-fluorobenzyl) tin Thiosalicylate

Key Laboratory of Functional Organometallic Materials of Hengyang Normal University, College of Hu'nan ProvinceDepartment of Chemistry and Material Science, Hengyang Normal University; , Hengyang, Hu'nan 421008, China

Corresponding author: ZHANG Fuxing, zfx8056@163.com; zfx8056@163.com
Received Date: 3 May 2016
Revised Date: 19 August 2016
Accepted Date: 28 September 2016

Fund Project: Scientific & Technological Projects of Hu′nan Province 2014NK3086the Scientific Research Fund of Hu′nan Provincial Education Department of China 15C0200Hu′nan Province University Innovation Platform of Open Fund Project 15K017Hu′nan Province University Innovation Platform of Open Fund Project 14K014Hu′nan Provincial Natural Science Foundation of China 13JJ3112the Scientific Research Fund of Hu′nan Provincial Education Department of China 15C0199Hu′nan Province University Innovation Platform of Open Fund Project 13K105

Figures(10)

Tris (o-methylbenzyl) tin thiosalicylate (1) and di (m-fluorobenzyl) tin thiosalicylate (2) have been synthesized. Crystal structures of the complexes were determined by X-ray diffraction. Crystal 1 belongs to the triclinic space group P₁ with a=1.00221(5) nm, b=1.48934(8) nm, c=1.71789(9) nm, α=78.3120(10)°, β=85.6560(10)°, γ=80.2580(10)°, V=2.4725(2) nm³, Z=2, D_c=1.371 g/cm³, μ(MoKα)=10.91 cm^-1, F(000)=1040, R₁=0.0439, wR₂=0.1119. Crystal 2 belongs to the monoclinic space group P2₁/n with a=1.17827(5) nm, b=2.11945(9) nm, c=1.55970(7) nm, β=93.4510(10)°, V=3.8880(3) nm³, Z=4, D_c=1.671 g/cm³, μ(MoKα)=14.53 cm^-1, F(000)=1936, R₁=0.0323, wR₂=0.0927. The tin atoms in complexes 1 and 2 have four coordinates in a distorted tetrahedral configuration and five coordinates in a distorted trigonal bipyramidal configuration, respectively. Further more, the thermal stability and electrochemical and anticancer activity of the complexes were tested. The results show that complexes 1 and 2 are stable below 152℃ and below 195℃, respectively, and show irreversible redox process. Complexes 1 and 2 display in vitro anti-tumor activity against five human tumor cell lines Colo205, Hep G2, MCF-7, Hela and NCI-H460, and the anti-tumor activity of complex 2 is higher than that of complex 1.
- tris (o-methylbenzyl) tin thiosalicylate,
- di (m-fluorobenzyl) tin thiosalicylate,
- crystal structure,
- in vitro anticancer activity,
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