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Citation: ZHANG Dunlin, XIA Fangfang, ZHOU Yefei, LIU Guangxiang, XUE Mengwei. Improved Synthesis, Crystal Structure and Fungicidal Activity of 2, 2'-Dithiobisbenzanilide[J]. Chinese Journal of Applied Chemistry, ;2017, 34(2): 158-162. doi: 10.11944/j.issn.1000-0518.2017.02.160133 shu

Improved Synthesis, Crystal Structure and Fungicidal Activity of 2, 2'-Dithiobisbenzanilide

a.
School of Environmental Science, Nanjing Xiaozhuang University, Nanjing 211171, China
b.
School of Food Science, Nanjing Xiaozhuang University, Nanjing 211171, China

Corresponding author: XUE Mengwei, xmw1102@sina.com; xmw1102@sina.com
Received Date: 30 March 2016
Revised Date: 21 September 2016
Accepted Date: 10 October 2016

Fund Project: Jiangsu Student′s Innovation and Entrepreneurship Training Program 201311460050X

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2, 2'-Dithiobisbenzanilide was synthesized with a total yield of 80% via oxidative condensation and acylation reaction. The title compound was extensively characterized by HRMS, NMR and single crystal X-ray diffraction. The single crystal X-ray structural analysis reveals that the crystal packing of the compound was stabilized by intramolecular C-H…O and C-H…S, intermolecular N-H…O and C-H…O interactions, and even Van der Waals force. The results show that the novel method is suitable for scale-up production with the advantages of easily obtained raw materials, easily conducted procedure and relatively high yield. Moreover, the compound shows excellent inhibitory activity against Botrytis cinerea, Sclerotinia sclerotiorum and Rhizoctonia solani.
- dithiobisbenzanilide,
- crystal structure,
- fungicidal activity
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