Citation: JIAN Yong, DING Ru, LIU Shu, LIU Zhongying, SONG Fengrui, LIU Zhiqiang. Comparison of the Pharmacokinetics Difference Between Acanthopanax Leaf Flavonoids Liposome and Acanthopanax Leaf Drop Pills[J]. Chinese Journal of Applied Chemistry, ;2017, 34(1): 118-122. doi: 10.11944/j.issn.1000-0518.2017.01.160132 shu

Comparison of the Pharmacokinetics Difference Between Acanthopanax Leaf Flavonoids Liposome and Acanthopanax Leaf Drop Pills

JIAN Yong ^a,b,c ,
DING Ru ^c ,
LIU Shu ^a,*,, ,
LIU Zhongying ^b ,
SONG Fengrui ^a ,
LIU Zhiqiang ^a

a.
National Center of Mass Spectrometry in Changchun & Jilin Province Key Laboratory of Chinese Medicine Chemistry and Mass Spectrometry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
b.
College of Pharmacy, Jilin University, Changchun 130021, China
c.
The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, China

Corresponding author: LIU Shu, mslab20@ciac.ac.cn
Received Date: 30 March 2016
Revised Date: 29 June 2016
Accepted Date: 29 June 2016

Figures(2)

Acanthopanax leaf flavonoids liposome, acanthopanax leaf drop pills, and acanthopanax leaf flavonoid extract were fed to rats by intragastric administration to study the bioavailability and pharmacokinetics of hyperoside, and appropriate dosage form of acanthopanax leaf flavonoid by liquid chromatography-tandem mass spectrometry(LC-MS/MS). Pharmacokinetic data were processed with PKsolver software. The main pharmacokinetic parameters maximum plasma concentrations(C_max) are (210.24±10.3), (254.12±9.2), and (349.34±12.5) μg/L for acanthopanax leaf flavonoids liposome, acanthopanax leaf drop pills and acanthopanax leaf flavonoid extract, respectively; area under the curve from zero to t(AUC_0-t) is (30.7±2.7), (35.01±1.98), and (45.2±2.8) μg/(mL·min), respectively; mean retention time(MRT) is (334.42±75.36), (394.56±90.26), and (640.35±84.26) min, respectively. The results show that compared with acanthopanax leaf flavonoids extracts and acanthopanax leaf drop pills, the C_max and bioavailability of acanthopanax leaf flavonoids liposome are increased, the elimination rate of acanthopanax leaf flavonoids liposome is reduced. Liposome is expected to be the suitable dosage form of acanthopanax leaf flavonoids, and may become the new research direction in the field of chinese medicine chemistry.
- acanthopanax,
- liposomes,
- dropping pills,
- bioavailability,
- pharmacokinetic
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