Citation: REN Lilei, PENG Xiaoxia, ZHAO Xiuli, ZHU Hongmei. Synthesis and Antitumor Activity of Porphyrin Modified with 5-Fluorouracil[J]. Chinese Journal of Applied Chemistry, ;2016, 33(12): 1415-1419. doi: 10.11944/j.issn.1000-0518.2016.12.160054 shu

Synthesis and Antitumor Activity of Porphyrin Modified with 5-Fluorouracil

1.
Faculty of Chemistry and Material Science, Langfang Teachers University, Hebei, Langfang 065000, China

Corresponding author: REN Lilei,
Received Date: 1 February 2016
Available Online: 12 April 2016
Fund Project:

The porphyrin modified with 5-fluorouracil(5-[2-(5-fluorouracil-3-yl)-ethoxyphenyl]-10,15,20-tri(4-methoxyphenyl) porphyrin) and its two metal porphyrin complexes:5-[2-(5-fluorouracil-3-yl)-ethoxyphenyl]-10,15,20-tri(4-methoxyphenyl) Mn porphyrin and 5-[2-(5-fluorouracil-3-yl)-ethoxyphenyl]-10,15,20-tri(4-methoxyphenyl) Zn porphyrin were synthesized. The structures of the three compounds were characterized by ultraviolet visible spectroscopy(UV-Vis), infred spectroscopy(IR) and proton nuclear magnetic resonance spectroscopy(¹H NMR). The antitumor activities of these compounds to A549, Bel7402, HCT-8 were tested using the methyl thiazolyl tetrazolium(MTT) method. The results show that the IC₅₀ value of Mn porphyrin to HCT-8 is 17.8 mg/L.
- porphyrin,
- fluorouracil,
- antitumor activity
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沈阳化工大学材料科学与工程学院沈阳 110142