Citation: SHI Yun, REN Chaojie, ZHANG Ning. Synthesis of Pyridines via Copper-catalyzed Reaction of Oxime Acetates with Benzyl Alcohols[J]. Chinese Journal of Applied Chemistry, ;2016, 33(11): 1289-1294. doi: 10.11944/j.issn.1000-0518.2016.11.160026 shu

Synthesis of Pyridines via Copper-catalyzed Reaction of Oxime Acetates with Benzyl Alcohols

1.
College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China

Corresponding author: SHI Yun,
Received Date: 15 January 2016
Available Online: 11 May 2016
Fund Project:

Pyridine derivatives were synthesized in a one-pot reaction from oxime acetates and benzyl alcohols in the presence of copper(Ⅱ) trifluoromethanesulfonate[Cu(OTf)₂] catalyst. The effect of catalysts and their dosage, raw material ratios, solvents, and temperatures on the yield were investigated. The target compound 2,4,6-trisubstituted pyridine was obtained in 88% yield under the optimum condition. The molecular structures of products were analyzed by mass spectrometry and nuclear magnetic resonance spectroscopy(¹H NMR and ¹³C NMR). The method has several advantages:commerically available materials, easy operation, mild reaction conditions, good yields and a wide range of functional group tolerance.
- oxime acetate,
- benzyl alcohol,
- copper-catalyzed,
- pyridine derivative,
- one-pot reaction
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沈阳化工大学材料科学与工程学院沈阳 110142