Citation: HUANG Zhining, ZHENG Manyi, MIAO Fangxiao, YU Jingqi, LI Shanhua, LI Funan, QU Ning. Synthesis and Anti-hepatoma Activities of N-(Piperidin-4-yl)benzamide Derivatives[J]. Chinese Journal of Applied Chemistry, ;2016, 33(6): 661-667. doi: 10.11944/j.issn.1000-0518.2016.06.150358 shu

Synthesis and Anti-hepatoma Activities of N-(Piperidin-4-yl)benzamide Derivatives

1.
a School of Pharmaceutical Sciences, Xiamen, Fujian 361102, China;
2.
b Medical College, Xiamen University, Xiamen, Fujian 361102, China

Corresponding author: QU Ning,
Received Date: 10 October 2015
Available Online: 23 December 2015
Fund Project:

Six benzamide derivatives were synthesized from 4-hydroxybenzoic acid via alkylation, hydrolysis and condensation reactions. The structure was confirmed by ¹H NMR, ¹³C NMR and MS. The antitumor activity of all the newly synthesized compounds was evaluated on the in vitro growth of HepG2 cell line using sorafeinb as positive control. The anti-hepatoma biological activity in vitro of N-(1-(methylsulfonyl)piperidin-4-yl)-4-phenoxybenzamide is better than that of sorafeinb with an IC₅₀ value of 8.42 μmol/L. The results show that the derivatives of N-(piperidin-4-yl)-4-phenoxybenzamide have good anti-hepatoma activity.
- benzamide,
- HepG2 cells,
- anti-hepatoma activity
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沈阳化工大学材料科学与工程学院沈阳 110142