Citation: LI Jie, LIU Yilin, DENG Youlin, WANG Wenxin, WANG Shuowen, LI Zengzeng, TANG Shi. Visible-Light-Induced Cyclization of Alkenes to Form Difluoroacetating Isoquinolinedione[J]. Chinese Journal of Applied Chemistry, ;2016, 33(6): 677-684. doi: 10.11944/j.issn.1000-0518.2016.06.150316 shu

Visible-Light-Induced Cyclization of Alkenes to Form Difluoroacetating Isoquinolinedione

LI Jie ^a ,
LIU Yilin ^b,, ,
DENG Youlin ^a ,
WANG Wenxin ^a ,
WANG Shuowen ^a ,
LI Zengzeng ^a ,
TANG Shi ^a,,

1.
a College of Chemistry and Chemical Engineering, Jishou University, Jishou, Hu'nan 427000, China;
2.
b Huaihua Key Laboratory of Functional Inorganic & Polymeric Materials, Huaihua University, Huaihua, Hu'nan 418008, China

Corresponding author: LIU Yilin, TANG Shi,
Received Date: 31 August 2015
Available Online: 23 December 2015
Fund Project:

A visible-light-induced cyclization reaction of activated alkenes leading to difluoroacetating isoquinolinedione was developed. By visible-light photoredox catalysis, various N-alkyl-N-methacryloyl benzamides underwent radical cascade cyclization smoothly and afforded a series of difluoroacetating isoquinolinediones in 66%~75% yields, providing a highly efficient, mild means to fluorinated isoquinolinediones with potential bioactivity.
- visible-light-induced,
- difluoroacetating,
- Ir photocatalyst,
- isoquinolinedione
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