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Citation: ZHANG Tianyi, NIAN Wenxia, JIN Ying. Organocatalytic Asymmetric Michael Addition of Anthrone with β-Nitroolefins[J]. Chinese Journal of Applied Chemistry, ;2015, 32(4): 422-427. doi: 10.11944/j.issn.1000-0518.2015.04.140313 shu

Organocatalytic Asymmetric Michael Addition of Anthrone with β-Nitroolefins

1.
Department of Pharmaceutical Chemistry, Jilin Medical College, Jilin, Jilin 132013, China

Corresponding author: JIN Ying,
Received Date: 9 September 2014
Available Online: 17 December 2014
Fund Project: 国家自然科学基金(21102055) (21102055)吉林省自然科学基金(201015237)资助项目 (201015237)

Cinchona alkaloid derivatives as organocatalysts were applied in asymmetric Michael addition reaction of anthrone with various trans-β-nitroolefins. Solvent,temperature and catalyst loading were screened.The optimized conditions are using toluene as the solvent with a 5%( molar fraction) loading of catalyst 1b at room temperature. The products are obtained in 91%~99% yield with up to 95% ee.
- Cinchona alkaloid derivative,
- organocatalysis,
- asymmetric Michael addition,
- anthrone,
- β-nitroolefins
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