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Citation: YANG Lei, FAN Lianghua, ZHAO Dandan, QI Binbin, GAN Chunfang, CUI Jian'guo, HUANG Yanmin. Synthesis and Antiproliferative Activity of 22-Abeostigmast-22-nitrogen-containing Compounds[J]. Chinese Journal of Applied Chemistry, ;2015, 32(3): 273-277. doi: 10.11944/j.issn.1000-0518.2015.03.140202 shu

Synthesis and Antiproliferative Activity of 22-Abeostigmast-22-nitrogen-containing Compounds

1.
a College of Chemistry and Life Science, Guangxi Teachers Education University, Nanning, Guangxi 530001, China;
2.
b Youth League Committee of Yongan, Sanming, Fujian 360000, China

Corresponding author: HUANG Yanmin,
Received Date: 10 June 2014
Available Online: 29 October 2014
Fund Project: 广西教育厅自然科学基金重点基金(201202ZD059)资助 (201202ZD059)

Using stigmasterol as a starting material,3β-acetoxycholest-5-ene-22-al was obtained by the protection of 3-hydroxyl and 5-double bond prior to the ozonolysis of 22-ene. Some 22-abeo-stigmast-22-nitrogen-containing compounds were synthesized by the condensation of aldehydes with semicarbazides and thiosemicarbazides. The structure of compounds were confirmed with NMR,IR and MS. Their antiproliferative activities against six kinds of cancer cells were evaluated with MTT method. Compound 8 with the 22-thiosemicarbazone group exhibits significant inhibitory activity on MGC 7901,Hela,SMMC 7404 and CNE-2cells with the IC₅₀ values of 10.5,11.6,8.7 and 11.9 μ mol/L,respectively.
- 22-abeo-stigmast-22-nitrogen-containing compounds,
- antiproliferative activity,
- synthesis
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