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Citation: XU Zhaohui, LIN Chunhua, LIAO Weilin. Efficient One-Pot Synthesis of 5-[(Indol-3-yl)-methyl]-2, 2-dimethyl-1, 3-dioxane-4, 6-dione Derivatives[J]. Chinese Journal of Applied Chemistry, ;2015, 32(3): 278-283. doi: 10.11944/j.issn.1000-0518.2015.03.140197 shu

Efficient One-Pot Synthesis of 5-[(Indol-3-yl)-methyl]-2, 2-dimethyl-1, 3-dioxane-4, 6-dione Derivatives

1.
Chemistry and Chemical Engineering Department, Jiangxi Normal University, Nanchang 330027, China

Corresponding author: XU Zhaohui,
Received Date: 5 June 2014
Available Online: 21 July 2014
Fund Project: 国家科技攻关计划(2001BA323C) (2001BA323C)江西省研究生创新基金(YC10A51)资助项目 (YC10A51)

Ten 5-[(indol-3-yl)-methyl]-2,2-dimethyl-1,3-dioxane-4,6-dione derivatives were synthesized by the three component condensation reaction of indole,aldehyde and 2,2-dimethyl-1,3-dioxane-4,6-dione using iodine as the catalyst. The results indicates that the yields range from 71.4% to 97.3% at 30℃ for 60~90 min using 5% molar fraction of iodine. Furthermore,a mechanism for the reaction catalyzed by iodine is proposed.
- dimethyl-dioxane-dione,
- iodine,
- aldehydes,
- three component condensation reaction
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