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Citation: LI Wenjuan, MA Junhuai, SONG Yumin. Synthesis,Characterization and Antitumor Activity of Rare Earth Metal Complexes with All-trans Retinoic Acid and L-Valine Acid[J]. Chinese Journal of Applied Chemistry, ;2015, 32(1): 34-42. doi: 10.11944/j.issn.1000-0518.2015.01.140152 shu

Synthesis,Characterization and Antitumor Activity of Rare Earth Metal Complexes with All-trans Retinoic Acid and L-Valine Acid

1.
College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, China

Corresponding author: SONG Yumin,
Received Date: 29 April 2014
Available Online: 12 June 2014
Fund Project: 国家自然科学基金(21062017) (21062017)甘肃省教育厅(1101-05) (1101-05)

In the medium of anhydrous ethanol,the complexes of REL₂L'·nH₂O(RE:Nd³⁺,Eu³⁺,La³⁺, Sc³⁺; L:all-trans retinoic acid; L':L-valine acid) were synthesized at 60℃. The compositions of these complexes were tested by means of infrared spectra(IR),ultraviolet spectra(UV),elemental analysis and TG-DTA methods. Meanwhile,the antitumor activity against HepG2,A549 and Hela in vitro growth cells was investigated by MTT test method. The results show that these four synthesized rare earth complexes inhibit the growth of HepG2,A549 and Hela cells in different degrees. The inhibition rates of these complexes are significantly higher than that of rare earth nitrate and ligands. The interaction of REL₂L' complex with DNA was studied by fluorescence spectroscopy and viscosity measurement. The results show that the type of interaction is mainly intercalation, which results in the antitumor activity of these complexes. This investigation provides certain ideas and experimental basis for the design of efficient rare earth antitumor drugs with low toxicity.
- rare earth complexes,
- synthesis and characterization,
- antitumor activity,
- ct-DNA
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