Citation: Bo YIN, Yamei ZHANG, Jihua ZHU, Yan FAN, Weien WANG, Zhenbin WANG. Glutathione-responsive Cu-TCPP metal-organic framework nanoprobe: Preparation and colorimetric detection performance[J]. Chinese Journal of Inorganic Chemistry, ;2026, 42(10): 2092-2098. doi: 10.11862/CJIC.20260157 shu

Glutathione-responsive Cu-TCPP metal-organic framework nanoprobe: Preparation and colorimetric detection performance

Bo YIN ^{1, 2, 3} ,
Yamei ZHANG ¹ ,
Jihua ZHU ^{1, 2, 3} ,
Yan FAN ^{1, 2, 3} ,
Weien WANG ^{1, 2, 3,,} ,
Zhenbin WANG ^{1, 2, 3,,}

1.
College of Chemistry & Chemical Engineering, Qinghai Normal University, Xining 810016, China
2.
Qinghai Key Laboratory of Advanced Technology and Application of Environmental Functional Materials, Xining 810016, China
3.
Academy of Plateau Science and Sustainability, People′s Government of Qinghai Province & Beijing Normal University, Xining 810016, China

Corresponding author: Weien WANG, weienwang@126.com Zhenbin WANG, wangzhbqhnu@163.com
Received Date: 6 May 2026
Revised Date: 31 August 2026

Figures(6)

Glutathione (GSH)-responsive nano-sized metal-organic framework (nMOF) materials, namely Cu-TCPP-nMOF, with tetrakis(4-carboxyphenyl)porphyrin (TCPP) as the ligand, were successfully synthesized based on the hydrothermal reaction method. Due to the presence of variable valence metals, this nanomaterial exhibited strong peroxidase-like activity. In the presence of H₂O₂, it could catalyze the reaction of the enzyme substrate 3, 3′, 5, 5′-tetramethylbenzidine (TMB), causing the color of the reaction system to change from colorless to blue. In addition, this nanomaterial can serve as a GSH-responsive colorimetric nanoprobes for highly sensitive detection of GSH. Cu-TCPP-nMOF could react with GSH, and the color of TMB+H₂O₂ system gradually faded with the gradual addition of GSH. The linear range of GSH detection was 10-60 μmol·L^-1, and the detection limit reached 1.20 μmol·L^-1.
- glutathione,
- nanoprobe,
- metal-organic frame work materials,
- colorimetric detection
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