Citation: Xuanxuan ZHANG, Shan YANG, Xing WANG, Fangzhu HUANG, Yujia XU, Cuiping HAN. Hyaluronic acid-modified manganese porphyrin MOF for activatable magnetic resonance imaging and synergistic sonodynamic-chemodynamic therapy performances[J]. Chinese Journal of Inorganic Chemistry, ;2026, 42(11): 2493-2503. doi: 10.11862/CJIC.20260070 shu

Hyaluronic acid-modified manganese porphyrin MOF for activatable magnetic resonance imaging and synergistic sonodynamic-chemodynamic therapy performances

Xuanxuan ZHANG ¹ ,
Shan YANG ¹ ,
Xing WANG ¹ ,
Fangzhu HUANG ¹ ,
Yujia XU ¹ ,
Cuiping HAN ^{1, 2,,}

1.
School of Medical Imaging, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China
2.
Department of Radiology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221000, China

Corresponding author: Cuiping HAN, hancp@xzhmu.edu.cn
Received Date: 4 March 2026
Revised Date: 27 August 2026

Figures(6)

A theranostic nanoprobe (HA-Mn-MOF) integrating T₁-weighted magnetic resonance imaging (MRI) with sonodynamic-chemodynamic synergistic therapy was constructed. The probe was based on a hyaluronic acid (HA)-modified manganese porphyrin metal-organic framework (MOF). HA-mediated active targeting enables tumor-specific enrichment, while the porphyrin units act as sonosensitizers to enhance the sonodynamic therapy (SDT) effect. The manganese centers not only deplete overexpressed glutathione (GSH) in the tumor microenvironment (TME) but also catalyze a Fenton-like reaction with endogenous H₂O₂, generating hydroxyl radical (·OH) and O₂ in situ. This chemodynamic therapy (CDT) simultaneously alleviates tumor hypoxia, significantly potentiating the SDT efficacy and thereby achieving efficient killing of breast cancer cells. Moreover, HA-Mn-MOF exhibited pH and GSH dual-responsive MRI activation, with a T₁ relaxation rate of 4.16 L·mmol^-1·s^-1, which was 2.7 times that under physiological conditions.
- metal-organic framework,
- sonodynamic therapy,
- magnetic resonance imaging,
- breast cancer,
- nanotheranostic probe
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