Citation: Haihuan YU, Jing SUN, Zhongmin SU. Research progress of water-stable metal-organic frameworks fluorescent sensors in food safety detection[J]. Chinese Journal of Inorganic Chemistry, ;2026, 42(8): 1569-1581. doi: 10.11862/CJIC.20260062 shu

Research progress of water-stable metal-organic frameworks fluorescent sensors in food safety detection

  • Corresponding author: Jing SUN, sj‐cust@126.com
  • Received Date: 27 February 2026
    Revised Date: 5 July 2026

Figures(6)

  • Developing rapid, sensitive, and highly selective on-site detection techniques is crucial for ensuring food safety. Metal-organic frameworks (MOFs), with their high specific surface area, tunable structures, and easy functionalization, exhibit great potential in fluorescence sensing. However, conventional MOFs suffer from insufficient water stability and tend to undergo framework hydrolysis and collapse in aqueous food matrices, which severely restricts their practical applications in food detection. This review systematically summarizes the synthesis strategies of highly water-stable MOFs based on "hard-soft acid-base (HSAB)" theory, steric hindrance effects, hydrophobic modification, and framework interlocking. In addition, typical fluorescence sensing mechanisms, including fluorescence quenching, fluorescence turn-on, and ratiometric fluorescence sensing, are discussed in detail. The latest advances of water-stable MOF-based fluorescence sensors in food safety detection are comprehensively reviewed, involving the detection of pesticide residues, antibiotics, heavy metal ions, foodborne pathogens, and food freshness monitoring. Finally, the current challenges and future development trends are prospected. This review aims to provide a theoretical basis and guidance for the design and application of water-stable MOF fluorescence sensors in complex food systems.
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