Citation: Qiang MA, Yiming ZHU, Meiqi HUA, Guangyu LU, Xingdong WANG, Hailong YU, Huan PANG, Yuping LI. Research progress on metal-organic frameworks as comprehensive carrier platforms for delivering anti-glioma drugs[J]. Chinese Journal of Inorganic Chemistry, ;2026, 42(4): 657-667. doi: 10.11862/CJIC.20250250 shu

Research progress on metal-organic frameworks as comprehensive carrier platforms for delivering anti-glioma drugs

Qiang MA ^{1, #} ,
Yiming ZHU ^{1, #} ,
Meiqi HUA ² ,
Guangyu LU ³ ,
Xingdong WANG ¹ ,
Hailong YU ⁴ ,
Huan PANG ^2,, ,
Yuping LI ^{1, 5,,}

1.
Department of Neurosurgery, Northern Jiangsu People′s Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu 225001, China
2.
School of Chemistry & Materials, Yangzhou University, Yangzhou, Jiangsu 225009, China
3.
School of Public Health, Yangzhou University, Yangzhou, Jiangsu 225001, China
4.
Department of Neuro-intensive Care unit, Northern Jiangsu People′s Hospital, Yangzhou, Jiangsu 225001, China
5.
Department of Neurosurgery, The Yangzhou Clinical Medical College of Xuzhou Medical University, Yangzhou, Jiangsu 225001, China

Corresponding author: Huan PANG, panghuan@yzu.edu.cn Yuping LI, yupingli@yzu.edu.cn
Received Date: 30 July 2025
Revised Date: 3 February 2026

Figures(5)

Metal-organic frameworks (MOFs) are a class of crystalline porous materials composed of organic ligands and metal ions/metal clusters. Due to their unique physical, chemical, and biological characteristics, they have become excellent platforms for drug delivery and play a significant role in the treatment of glioma. This article reviews the latest progress in MOFs for glioma treatment, including research advancements in drug penetration through the blood-brain barrier (BBB), targeted delivery of anti-glioma drugs, controlled drug release, and multiple-drug combination therapy. The aim is to provide a reference basis for the application and promotion of MOFs in glioma treatment.
- glioma,
- nanomaterials,
- metal-organic frameworks
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沈阳化工大学材料科学与工程学院沈阳 110142