Citation: Jia JI, Tengqi YAO, Wenqian DENG, Wenjing SHI, Xuan LÜ, Lin TIAN, Xiaoyan XIN, Yinling HOU. Structures, antibacterial activities, and interactions with DNA of two nickel complexes[J]. Chinese Journal of Inorganic Chemistry, ;2026, 42(1): 78-86. doi: 10.11862/CJIC.20250141 shu

Structures, antibacterial activities, and interactions with DNA of two nickel complexes

Jia JI ¹ ,
Tengqi YAO ¹ ,
Wenqian DENG ¹ ,
Wenjing SHI ¹ ,
Xuan LÜ ¹ ,
Lin TIAN ¹ ,
Xiaoyan XIN ^2,, ,
Yinling HOU ^1,,

1.
Key Laboratory of Preparation and Application of Micro & Mesoporous Nanomaterials of Guizhou Provincial Department of Education, Kaili University, Kaili, Guizhou 556011, China
2.
Civil Aviation Modern Industry College, Ningxia Institute of Science and Technology, Shizuishan, Ningxia 753000, China

Corresponding author: Xiaoyan XIN, 1624889278@qq.com Yinling HOU, hyl0506@126.com
Received Date: 25 April 2025
Revised Date: 26 September 2025

Figures(9)

Through in situ reaction, two complexes [Ni(HL₁)₂]·CH₃CN·CH₃OH (1) and [Ni(L₂)₂] (2), where H₂L₁=2-hydroxy-benzoic acid (6-methoxy-pyridin-2-ylmethylene)-hydrazide and HL₂=4-bromo-2-[(6-methoxy-pyridin-2-ylmethylene)-amino]-phenol, were designed and synthesized. A comprehensive analysis of the complexes' structures and properties was performed using single-crystal X-ray diffraction, infrared spectroscopy, thermogravimetric analysis, powder X-ray diffraction, and X-ray photoelectron spectroscopy. Single crystal X-ray diffraction results show that both complexes 1 and 2 are centered on Ni²⁺ ions and form a mononuclear zero-dimensional structure. The antibacterial properties of complexes 1-2 were investigated using the agar well diffusion method, and the results show that both complexes have more potent antibacterial activity compared to a single transition metal nickel ion. The interaction between complexes 1-2 and calf thymus DNA (CTDNA) was studied using UV-Vis spectroscopy, the cyclic voltammetry method, and fluorescence spectroscopy. The results show that the two complexes bind to CTDNA mainly through intercalation.
- Ni complexes,
- in situ synthesis,
- crystal structures,
- biological activities,
- DNA-interaction
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