Citation: Ruifeng CHEN, Chao XU, Jianting JIANG, Tianshe YANG. Gold nanorod/zinc oxide/mesoporous silica nanoplatform: A triple-modal platform for synergistic anticancer therapy[J]. Chinese Journal of Inorganic Chemistry, ;2025, 41(11): 2272-2282. doi: 10.11862/CJIC.20250117 shu

Gold nanorod/zinc oxide/mesoporous silica nanoplatform: A triple-modal platform for synergistic anticancer therapy

State Key Laboratory of Flexible Electronics (LoFE) & Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, Nanjing 210023, China

Corresponding author: Tianshe YANG, iamtsyang@njupt.edu.cn
Received Date: 3 April 2025
Revised Date: 1 July 2025

Figures(6)

Herein, we engineered a multifunctional nanoplatform DOX-AuNR@ZnO@SiO₂ (DOX=doxorubicin, AuNR=gold nanorod) by integrating photothermal therapy, reactive oxygen species (ROS)-mediated oxidative damage, and chemotherapy. The system was constructed by sequentially decorating AuNR with a ZnO layer for ROS generation and a mesoporous silica (mSiO₂) shell for biocompatibility enhancement and DOX loading. The nanocomposite exhibited a well-defined core-shell structure with uniform size, excellent colloidal stability, and favorable bio-compatibility. Under near-infrared (NIR) irradiation, the AuNR core demonstrated remarkable photothermal conversion efficiency (20.85%) and photostability over multiple cycles. NIR-triggered thermal expansion can enhance the release of DOX from mesoporous SiO₂. Simultaneously, ZnO-mediated cytotoxic ROS were generated to synergize with photothermal ablation and chemotherapy. In vitro evaluations using HeLa cells revealed triple-modal therapeutic efficacy with superior tumor suppression. The rationally designed nanoplatform successfully integrates chemotherapy, photothermal therapy, and ROS-mediated therapy.
- gold nanorod,
- zinc oxide,
- mesoporous silica,
- triple-modal therapy
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沈阳化工大学材料科学与工程学院沈阳 110142