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Citation: Yingyue ZHANG, Liuqing KANG, Yating YANG, Xiaofen GUAN, Wenmin WANG. Crystal structure and antibacterial activity of two Gd2 complexes based on polydentate Schiff-base ligands[J]. Chinese Journal of Inorganic Chemistry, ;2025, 41(9): 1867-1877. doi: 10.11862/CJIC.20250100 shu

Crystal structure and antibacterial activity of two Gd2 complexes based on polydentate Schiff-base ligands

  • College of Chemistry and Materials, Taiyuan Normal University, Jinzhong, Shanxi 030619, China

Figures(6)

  • Two Gd2 complexes, namely [Gd2(dbm)2(HL1)2(CH3OH)2]·4CH3OH (1) and [Gd2(dbm)2(L2)2(CH3OH)2]·2CH3OH (2), where H3L1=(Z)-N′-[4-(diethylamino)-2-hydroxybenzylidene]-2-hydroxyacetohydrazide, H2L2=(E)-N′- (5-bromo-2-hydroxy-3-methoxybenzylidene)nicotinohydrazide, Hdbm=dibenzoylmethane, have been constructed by adopting the solvothermal method. Structural characterization unveils that both complexes 1 and 2 are constituted by two Gd3+ ions, two dbm- ions, two CH3OH molecules, and two polydentate Schiff-base ligands (HL12- or L22-). In addition, complex 1 contains four free methanol molecules, whereas complex 2 harbors two free methanol molecules. By investigating the interactions between complexes 1 and 2 and four types of bacteria (Bacillus subtilis, Escherichia coli, Staphylococcus aureus, Candida albicans), it was found that both complexes 1 and 2 exhibited potent antibacterial activities. The interaction mechanisms between the ligands H3L1, H2L2, complexes 1 and 2, and calf thymus DNA (CT-DNA) were studied using ultraviolet-visible spectroscopy, fluorescence titration, and cyclic voltammetry. The results demonstrated that both complexes 1 and 2 can intercalate into CT-DNA molecules, thereby inhibiting bacterial proliferation to achieve the antibacterial effects.
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