Citation: Qiang HU, Zhiqi CHEN, Zhong CHEN, Xu WANG, Weina WU. Pyridinium-chalcone-based ClO^- fluorescent probe: Preparation and biological imaging applications[J]. Chinese Journal of Inorganic Chemistry, ;2025, 41(9): 1789-1795. doi: 10.11862/CJIC.20250086 shu

Pyridinium-chalcone-based ClO^- fluorescent probe: Preparation and biological imaging applications

Qiang HU ¹ ,
Zhiqi CHEN ² ,
Zhong CHEN ² ,
Xu WANG ^3,, ,
Weina WU ^4,,

1.
School of Physics and Electronic Information Engineering, Henan Polytechnic University, Jiaozuo, Henan 454000, China
2.
School of Materials and Energy, Jiangxi Science and Technology Normal University, Nanchang 330013, China
3.
Lucky Huaguang Graphics Co., Ltd., Nanyang, Henan 473006, China
4.
College of Chemistry and Chemical Engineering, Henan Polytechnic University, Jiaozuo, Henan 454000, China

Corresponding author: Xu WANG, 573907861@qq.com Weina WU, wuwn08@hpu.edu.cn
Received Date: 15 March 2025
Revised Date: 2 July 2025

Figures(6)

A pyridinium-chalcone-based probe (1) was prepared via a two-step reaction, which was characterized through ¹H NMR and mass spectra. Probe 1 was weakly emissive in water-sufficient solution, while hypochlorite (ClO^-) could remarkably enhance the yellow fluorescence emission of the probe at 550 nm. The detection of probe 1 for ClO^- had the advantages of fast response (< 30 s), high sensitivity (a detection limit of 0.4 μmol·L^-1), and large Stokes shift (130 nm). The ClO^--promoted oxidation-elimination of probe 1 was suggested by mass spectra and theoretical calculation methods. Furthermore, the probe was successfully used to monitor mitochondrial ClO^- in living cells and zebrafish.
- biological imaging,
- chalcone,
- fluorescent probe,
- hypochlorite,
- mitochondria-targeting
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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Pyridinium-chalcone-based ClO- fluorescent probe: Preparation and biological imaging applications

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通讯作者: 陈斌, bchen63@163.com

Pyridinium-chalcone-based ClO^- fluorescent probe: Preparation and biological imaging applications