Citation: Cun WANG, Shaohan XU, Yuqian ZHANG, Yaoyao ZHANG, Tao GONG, Rong WEN, Yuhang LIAO, Yanrong REN. Terbium complex electrochemiluminescent emitters: Synthesis and application in the detection of epinephrine[J]. Chinese Journal of Inorganic Chemistry, ;2025, 41(7): 1351-1360. doi: 10.11862/CJIC.20240427 shu

Terbium complex electrochemiluminescent emitters: Synthesis and application in the detection of epinephrine

Chongqing Key Laboratory of Medicinal Resources in the Three Gorges Reservoir Region, School of Biological and Chemical Engineering, Chongqing University of Education, Chongqing 400067, China

Corresponding author: Yanrong REN, renyr@cque.edu.cn
Received Date: 4 December 2024
Revised Date: 6 May 2025

Figures(8)

To accurately detect epinephrine (EP), in this work, three lanthanide terbium complexes (α-Tb-CCP, β-Tb-CCP, and γ-Tb-CCP) as cathode electrochemiluminescence (ECL) luminophores were synthesized via a simple hydrothermal synthesis method, and the β-Tb-CCP with the highest ECL intensity was chosen. The highest ECL signal of β-Tb-CCP is mainly attributed to its small size and surface aperture. Finally, a sensitive ECL sensor for EP detection was constructed with β-Tb-CCP as the luminophore, EP as the signal quencher, and flower-shaped zinc oxide as the ECL signal stabilizer and co-reaction accelerator. In a range of 0.1 pmol·L^-1 to 10 mmol·L^-1, the ECL intensity difference ΔI (ΔI=I₀-I, where I₀ and I correspond to the blank ECL intensity without EP and with EP, respectively) showed a good quantitative linear relationship with the logarithm of EP concentration (lg c). The linear equation was ΔI=684.3lg c+9 443.0 (R²=0.9978), and the detection limit was 18.2 fmol·L^-1 (S/N=3). In addition, the detection results of EP hydrochloride injection were 0.954 mg: 1 mL and 4.883 mg: 5 mL, which were close to the declared EP contents in the injection.
- terbium complex,
- electrochemiluminescence,
- epinephrine,
- sensor
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