Citation: Rui TIAN, Duo LI, Yuan REN, Jiamin CHAI, Xuehua SUN, Haoyu LI, Yuecheng ZHANG. Dual-ligand-modified copper nanoclusters: Synthesis and application in ornidazole detection[J]. Chinese Journal of Inorganic Chemistry, ;2025, 41(6): 1245-1255. doi: 10.11862/CJIC.20240389 shu

Dual-ligand-modified copper nanoclusters: Synthesis and application in ornidazole detection

Collage of Chemistry and Chemical Engineering, Yan'an University, Yan'an, Shannxi 716000, China

Corresponding author: Rui TIAN, tianrui100@163.com
Received Date: 30 October 2024
Revised Date: 9 April 2025

Figures(6)

Bovine serum albumin (BSA) and glycine (Gly) dual-ligand-modified copper nanoclusters (BSA-Gly CuNCs) with high fluorescence intensity were synthesized by a one-pot strategy. Based on the competitive fluorescence quenching and dynamic quenching effects of ornidazole (ONZ) on BSA-Gly CuNCs, a simple and sensitive detection method for ONZ was successfully developed. The experimental results demonstrate that the addition of the small molecule Gly can more effectively protect CuNCs, and thus enhance its fluorescence intensity and stability. The proposed assay allowed for the detection of ONZ in a linear range of 0.28 to 52.60 μmol·L^-1 and a detection limit of 0.069 μmol·L^-1. Compared with the single-ligand-modified CuNCs, dual-ligand-modified BSA-Gly CuNCs had higher fluorescence intensity, stability, and sensing ability and were successfully applied to evaluate ONZ in actual ONZ tablets.
- copper nanocluster,
- ornidazole,
- dual-ligand-modified,
- fluorescence detection
1. [1]
  DU R B, BA K, YANG Y X, ZHAO Y Y, LIN Y P. Efficacy of ornidazole for pericoronitis: A meta-analysis and systematic review[J]. Arch. Med. Sci., 2024,20(1):189-195. doi: 10.5114/aoms/171907
2. [2]
  LI S C, CAO M, ZHOU Y, SHU C, WANG Y. Ornidazole transfer into colostrum and assessment of exposure risk for breastfeeding infant: A population pharmacokinetic analysis. pharmaceutics[J]. Pharmaceutics, 2023,15(11)2524. doi: 10.3390/pharmaceutics15112524
3. [3]
  HARIKA S C, KUMAR Y S, RAO Y M, SRIRAM P, SHANKAR U. Design and evaluation of sustained release of ornidazole by dental inserts[J]. Curr. Drug Metab., 2021,22(7):572-580. doi: 10.2174/1389200222666210222152940
4. [4]
  GÓMEZ-MUÑOZ M T, GÓMEZ-MOLINERO M Á, GONZÁLEZ F, AZAMI-CONESA I, BAILÉN M, GARCÍA PIQUERAS M. Avian oropharyngeal trichomonosis: Treatment, failures and alternatives, a systematic review[J]. Microorganisms, 2022,10(11)2297. doi: 10.3390/microorganisms10112297
5. [5]
  ETTADILI F E, AZRIOUIL M, MATROUF M, TAHIRI ALAOUI O, LAGHRIB F, FARAHI A. Materials framework based biosensors for the detection of ornidazole and metronidazol antibiotics in environment and foodstuffs[J]. Inorg. Chem. Commun., 2022,140109416. doi: 10.1016/j.inoche.2022.109416
6. [6]
  MANCIU F S, GUERRERO J, PENCE B C, MARTINEZ LOPEZ L V. Assessment of drug activities against giardia using hyperspectral Raman microscopy[J]. Pathogens, 2024,13(5)358. doi: 10.3390/pathogens13050358
7. [7]
  MEMIŞ A C, ALCAN S Y, TEMIZ S G, BAŞAR F, ARSLAN K. Managing unpredictable challenge of a liver injury in ornidazole use: A case report[J]. Med. Rep., 2024,6100097.
8. [8]
  ZHANG L Y, ZHANG Z J, WU K. In vivo and real time determination of ornidazole and tinidazole and pharmacokinetic study by capillary electrophoresis with microdialysis[J]. J. Pharm. Biomed. Anal., 2006,41(4):1453-1457. doi: 10.1016/j.jpba.2006.03.016
9. [9]
  SEE K L, ELBASHIR A A, SAAD B, ALI A S M, ABOUL-ENEIN H Y. Simultaneous determination of ofloxacin and ornidazole in pharmaceutical preparations by capillary zone electrophoresis[J]. Biomed. Chromatogr., 2009,23(12):1283-1290. doi: 10.1002/bmc.1251
10. [10]
  BABU N R D. Development and validation of stability indicating RP-HPLC method for quantitative estimation of ornidazole and its impurities in ornidazole injection[J]. Res. J. Pharm. Technol., 2022,25(2):82-88.
11. [11]
  AGRAWAL G P, MAHESHWARI R K, MISHRA P. Validation of ultra performance liquid chromatography-tandem mass spectrometry coupled with electrospray ionization method for quantitative determination of ornidazole in solid dispersion[J]. Curr. Pharm. Anal., 2020,16(5):487-493. doi: 10.2174/1573412914666181024145937
12. [12]
  KELANI K M, GAD A G, FAYEZ Y M, MAHMOUD A M, ABDEL-RAOOF A M. Three developed spectrophotometric methods for determination of a mixture of ofloxacin and ornidazole; Application of greenness assessment tools[J]. BMC Chem., 2023,17(1)16. doi: 10.1186/s13065-023-00932-3
13. [13]
  KUMAR VASHISTHA V, BALA R, VSR PULLABHOTLA R. Derivatizing agents for spectrophotometric and spectrofluorimetric determination of pharmaceuticals: A review[J]. J. Taibah Univ. Sci., 2023,17(1)2206363. doi: 10.1080/16583655.2023.2206363
14. [14]
  EL HAYAOUI W, TAJAT N, RADAA C, BOUGDOUR N, ZOUBIR J, IDELAHCEN A. In situ preparation of eggshell@Ag nanocomposite electrode for highly sensitive detection of antibiotic drug ornidazole in water sample[J]. Nanotechnol. Environ. Eng., 2022,7(3):635-646. doi: 10.1007/s41204-022-00272-y
15. [15]
  WANG H X, BO X J, ZHOU M, GUO L P. DUT-67 and tubular polypyrrole formed a cross-linked network for electrochemical detection of nitrofurazone and ornidazole[J]. Anal. Chim. Acta, 2020,1109:1-8. doi: 10.1016/j.aca.2020.03.002
16. [16]
  ZHAO L, LI J Y, LI Y, WANG T G, JIN X L, WANG K, RAHMAN E, XING Y, JI B P, ZHOU F. Preparation of monoclonal antibody and development of an indirect competitive enzyme-linked immunosorbent assay for ornidazole detection[J]. Food Chem., 2017,229:439-444. doi: 10.1016/j.foodchem.2017.02.100
17. [17]
  RAWAT A, KANZARIYA D B, LAMA P, PAL T K. A Zn²⁺ coordination polymer as a dual sensor for ppb level detection of antibiotics and organo-toxins in a green solvent[J]. Spectroc. Acta Pt. A‒Molec. Biomolec. Spectr., 2023,295122579. doi: 10.1016/j.saa.2023.122579
18. [18]
  MAGDY G, ABOELKASSIM E, EL-DOMANY R A, BELAL F. Green synthesis, characterization, and antimicrobial applications of silver nanoparticles as fluorescent nanoprobes for the spectrofluori-metric determination of ornidazole and miconazole[J]. Sci. Rep., 2022,12(1)21395.
19. [19]
  SONG X M, HOU X F, DANG M X, ZHAO Q X, LIU S, MA Z H, REN Y X. Design and preparation of a multi-responsive Cd-based fluorescent coordination polymer for smart sensing of nitrobenzene and ornidazole[J]. Spectroc. Acta Pt. A ‒ Molec. Biomolec. Spectr., 2024,320124656.
20. [20]
  BAO H L, LIU Y H, LI H, QI W X, SUN K Y. Luminescence of carbon quantum dots and their application in biochemistry[J]. Heliyon, 2023,9(10)e20317.
21. [21]
  LEONG C Y, WAHAB R A, LEE S L, PONNUSAMY V K, CHEN Y H. Current perspectives of metal-based nanomaterials as photocatalytic antimicrobial agents and their therapeutic modes of action: A review[J]. Environ. Res., 2023,227115578.
22. [22]
  PEI G X, ZHANG L L, SUN X Y. Recent advances of bimetallic nanoclusters with atomic precision for catalytic applications[J]. Coord. Chem. Rev., 2024,506215692.
23. [23]
  KAWAWAKI T, EBINA A, HOSOKAWA Y, OZAKI S, SUZUKI D, HOSSAIN S. Thiolate-protected metal nanoclusters: Recent development in synthesis, understanding of reaction, and application in energy and environmental field[J]. Small, 2021,17(27)2005328.
24. [24]
  MATUS M F, HÄKKINEN H. Understanding ligand-protected noble metal nanoclusters at work[J]. Nat. Rev. Mater., 2023,8(6):372-389.
25. [25]
  BURRATTI L, CIOTTA E, BOLLI E, KACIULIS S, CASALBONI M, DE MATTEIS F, GARZON-MANJON A, SCHEU C, PIZZOFERRATO R, PROSPOSITO P. Fluorescence enhancement induced by the interaction of silver nanoclusters with lead ions in water[J]. Colloid Surf. A-Physicochem. Eng. Asp., 2019,579123634.
26. [26]
  XUE R, GENG X, LIANG F, LIU Y, YANG W, HUANG Z. Natural plant compounds in synthesis and luminescence modulation of metal nanoclusters: Toward sustainable nanoprobes for sensing and bioimaging[J]. Mater. Today Adv., 2022,16100279. doi: 10.1016/j.mtadv.2022.100279
27. [27]
  ZOU X J, KANG X, ZHU M Z. Recent developments in the investigation of driving forces for transforming coinage metal nanoclusters[J]. Chem. Soc. Rev., 2023,52(17):5892-5967. doi: 10.1039/D2CS00876A
28. [28]
  YANG J, YANG F, ZHANG C S, HE X B, JIN R C. Metal nanoclusters as biomaterials for bioapplications: Atomic precision as the next goal[J]. ACS Mater. Lett., 2022,4(7):1279-1296. doi: 10.1021/acsmaterialslett.2c00237
29. [29]
  NIE Y M, TAO X L, ZHANG H W, CHAI Y Q, YUAN R. Self-assembly of gold nanoclusters into a metal-organic framework with efficient electrochemiluminescence and their application for sensitive detection of rutin[J]. Anal. Chem., 2021,93(7):3445-3451. doi: 10.1021/acs.analchem.0c04682
30. [30]
  XIE B, DING B S, MAO P, WANG Y, LIU Y N, CHEN M R, ZHOU C J, WEN H M, XIA S J, HAN M, PALMER R E, WANG G G, HU J. Metal nanocluster-metal organic framework-polymer hybrid nanomaterials for improved hydrogen detection[J]. Small, 2022,18(23)2200634. doi: 10.1002/smll.202200634
31. [31]
  XU J, LI J M, ZHONG W C, WANG M Y, SUKHUROROKOV G, LI S. The density of surface ligands regulates the luminescence of thiolated gold nanoclusters and their metal ion response[J]. Chin. Chem. Lett., 2021,32(8):2390-2394. doi: 10.1016/j.cclet.2021.02.037
32. [32]
  JIANG M Z, XU X Y, LIU S, LIU L L, WANG X M, JIANG H. Enhancement of nanozyme activity by second ligand modification on glutathione protected gold nanoclusters for regulation of intracellular oxidative stress[J]. Inorg. Chem. Commun., 2024,161112115. doi: 10.1016/j.inoche.2024.112115
33. [33]
  ZHAO P, XU L J, LI B H, ZHAO Y F, ZHAO Y S, LU Y, CAO M H, LI G Q, WENG T C, WANG H, ZHENG Y J. Non-equilibrium assembly of atomically-precise copper nanoclusters[J]. Adv. Mater., 2024,36(28)2311818. doi: 10.1002/adma.202311818
34. [34]
  ZHANG L L, WONG W Y. Atomically precise copper nanoclusters as ultrasmall molecular aggregates: Appealing compositions, structures, properties, and applications[J]. Aggregate, 2023,4(1)e266. doi: 10.1002/agt2.266
35. [35]
  OUYANG X Y, WANG M F, GUO L J, CUI C J, LIU T, REN Y G, ZHAO Y, GUO X N, XIE G, LI J, FAN C H, WANG L H. DNA nanoribbon-templated self-assembly of ultrasmall fluorescent copper nanoclusters with enhanced luminescence[J]. Angew. Chem.‒Int. Edit., 2020,59(29):11836-11844. doi: 10.1002/anie.202003905
36. [36]
  BARNWAL N H, NANDI N, SARKAR P, SAHU K. White light emission from Zn²⁺ and DMSO-induced copper nanocluster assembly[J]. Chem.‒Asian J., 2024,9(9)e202400633.
37. [37]
  HUANG X, ZHAO H N, QIU W, WANG J, GUO L H, LIN Z Y, PAN W, WU Y, QIU B. A fluorescence signal amplification strategy for modification-free ratiometric determination of tyrosinase in situ based on the use of dual-templated copper nanoclusters[J]. Microchim. Acta, 2020,240(4)240.
38. [38]
  PU S, XIA C Y, WU L, XU K L. CuNCs modified with dual-ligand to achieve fluorescence visualization detection of Tin (Ⅳ)[J]. Microchem. J., 2022,183(20)108086.
39. [39]
  FAN Y, YU W H, LIAO Y W, JIANG X H, WANG Z H, CHENG Z J. Ratiometric detection of doxycycline in pharmaceutical based on dual ligands-enhanced copper nanoclusters[J]. Spectroc. Acta Pt. A‒Molec. Biomolec. Spectr., 2022,267120509. doi: 10.1016/j.saa.2021.120509
40. [40]
  BİLKAY M, KARA H. Fluorometric determination of ornidazole by using BSA coated copper nanoclusters as a novel turn off sensor[J]. Turk. J. Chem., 2022,46(2):475-486. doi: 10.55730/1300-0527.3321
41. [41]
  NAWARA K, WALUK J. Improved method of fluorescence quantum yield determination[J]. Anal. Chem., 2017,89(17):8650-8655. doi: 10.1021/acs.analchem.7b02013
42. [42]
  KALIA A, KAUR G. Biosynthesis of nanoparticles using mushrooms[M]//SINGH B, LALLAWMSANGA, PASSARI A. Biology of Macrofungi. Fungal Biology. [S. l.]: Springer, Cham, 2018.
43. [43]
  BARTH A. Infrared spectroscopy of proteins[J]. Biochim. Biophys. Acta, 2007,1767(9):1073-1101. doi: 10.1016/j.bbabio.2007.06.004
44. [44]
  DING C F, XU Y J, ZHAO Y N, ZHONG H, LUO X L. Fabrication of BSA@AuNC-based nanostructures for cell fluoresce imaging and target drug delivery[J]. ACS Appl. Mater. Interfaces, 2018,10(10):8947-8954. doi: 10.1021/acsami.7b18493
45. [45]
  LE GUÉVEL X, HÖTZER B, JUNG G, HOLLEMEYER K, TROUILLET V, SCHNEIDER M. Formation of fluorescent metal (Au, Ag) nanoclusters capped in bovine serum albumin followed by fluorescence and spectroscopy[J]. J. Phys. Chem. C, 2011,115(22):10955-10963. doi: 10.1021/jp111820b
46. [46]
  WANG L, MIAO H, ZHONG D, YANG X M. Synthesis of dopamine-mediated Cu nanoclusters for sensing and fluorescent coding[J]. Anal. Methods, 2016,8(1):40-44. doi: 10.1039/C5AY02494C
47. [47]
  VILAR-VIDAL N, BLANCO M C, LOPEZ-QUINTELA M A. Electrochemical synthesis of very stable photoluminescent copper cluster[J]. J. Phys. Chem. B, 2010,114(38):15924-15930.
48. [48]
  HAN A, YANG Y, ZHANG Q, TU Q, FANG G, LIU J, WANG S, LI R. Electrochemistry and electrochemiluminescence of copper metal cluster[J]. J. Electroanal. Chem., 2017,795:116-122. doi: 10.1016/j.jelechem.2017.04.058
49. [49]
  YANG B, YANG F Z, HUANG L, XU S K, YAO G H, ZHOU S M. Study on the role of 2, 2-bipyridine in chemical copper plating[J]. Electrochemistry, 2007,13(4):425-430.
50. [50]
  ZHAO M, CHEN A Y, HUANG D, ZHUO Y, CHAI Y Q, YUAN R. Cu nanoclusters: Novel electrochemiluminescence emitters for bioanalysis[J]. Anal. Chem., 2016,88:11527-11532. doi: 10.1021/acs.analchem.6b02770
51. [51]
  BALOGH L, VALLUZZI R, LAVERDURE K S, GIDO S P, HAGNAUER G L, TOMALIA D A. Poly (amidoamine) dendrimer-templated nanocomposites. 1. Synthesis of zerovalent copper nanoclusters[J]. J. Am. Chem. Soc., 1998,120(29):7355-7356. doi: 10.1021/ja980861w
52. [52]
  PAN Y, WEI X L. A novel FRET immunosensor for rapid and sensitive detection of dicofol based on bimetallic nanoclusters[J]. Anal. Chim. Acta, 2022,1224340235. doi: 10.1016/j.aca.2022.340235
53. [53]
  MATOSSI F. Theory of dynamic quenching of photoconductivity and luminescence[J]. J. Electrochem. Soc., 1956,103(12):662-667. doi: 10.1149/1.2430187
54. [54]
  XU Y L, SHERWOOD J, QIN Y, CROWLEY D, BONIZZONI M, BAO Y. The role of protein characteristics in the formation and fluorescence of Au nanoclusters[J]. Nanoscale, 2014,6(3):1515-1524. doi: 10.1039/C3NR06040C
55. [55]
  ANDREWS B, TORRIE B H, POWELL B M. Intermolecular potentials for alpha-glycine from Raman and infrared scattering measurements[J]. Biophys. J., 1983,41(3):293-298. doi: 10.1016/S0006-3495(83)84441-5
56. [56]
  TIAN L, LI Y F, REN T T, TONG Y L, YANG B S, LI Y Q. Novel bimetallic gold-silver nanoclusters with "Synergy"-enhanced fluorescence for cyanide sensing, cell imaging and temperature sensing[J]. Talanta, 2017,170:530-539. doi: 10.1016/j.talanta.2017.03.107
57. [57]
  THULKAR J, KRIPLANI A, AGARWAL N. A comparative study of oral single dose of metronidazole, tinidazole, secnidazole and ornidazole in bacterial vaginosis[J]. Indian J. Pharmacol., 2012,44(2):243-245. doi: 10.4103/0253-7613.93859
58. [58]
  KURT Ö, GIRGINKARDESLER N, BALCIOGLU I C, ÖZBILGIN A, OK Ü Z. A comparison of metronidazole and single-dose ornidazole for the treatment of dientamoebiasis[J]. Clin. Microb. Infect., 2008,14(6):601-604. doi: 10.1111/j.1469-0691.2008.02002.x
59. [59]
  LEI M Y, WANG X H, ZHANG T J, SHI Y, WEN J H, ZHANG Q F. Homochiral Eu³⁺@MOF composite for the enantioselective detection and separation of (R/S)-ornidazole[J]. Inorg. Chem., 2022,61(18):6764-6772. doi: 10.1021/acs.inorgchem.1c03695
60. [60]
  CARTER D C, HO J X. Structure of serum albumin[J]. Adv. Protein Chem., 1994,45:153-203.
61. [61]
  CHEN X L, LIU L, SHANG L, CAI M, CUI H L, YANG H, WANG J J. A highly sensitive and multi-responsive Zn-MOF fluorescent sensor for detection of Fe³⁺, 2, 4, 6-trinitrophenol, and ornidazole[J]. Chinese J. Inorg. Chem., 2022,38(4):735-744.
1. [1]
  Rui TIAN , Jiamin CHAI , Junyu CHEN , Yuan REN , Xuehua SUN , Haoyu LI , Yuecheng ZHANG . Chitosan/silica-coated copper nanoclusters: Synthesis and application in cefixime detection. Chinese Journal of Inorganic Chemistry, 2025, 41(9): 1903-1915. doi: 10.11862/CJIC.20250026
2. [2]
  Xuehua SUN , Min MA , Jianting LIU , Rui TIAN , Hongmei CHAI , Huali CUI , Loujun GAO . Pr/N co-doped biomass carbon dots with enhanced fluorescence for efficient detection of 2,4-dinitrophenylhydrazine. Chinese Journal of Inorganic Chemistry, 2025, 41(3): 561-573. doi: 10.11862/CJIC.20240294
3. [3]
  Lei ZHANG , Cheng HE , Yang JIAO . An azo-based fluorescent probe for the detection of hypoxic tumor cells. Chinese Journal of Inorganic Chemistry, 2025, 41(6): 1162-1172. doi: 10.11862/CJIC.20250081
4. [4]
  Yang LIU , Jin TONG , Shuyan YU . Co(Ⅱ) coordination polymers: Structural characterization and fluorescence sensing of Al³⁺ in aqueous. Chinese Journal of Inorganic Chemistry, 2025, 41(11): 2399-2408. doi: 10.11862/CJIC.20250114
5. [5]
  Xiaofei NIU , Ke WANG , Fengyan SONG , Shuyan YU . Self-assembly of [Pd₆(L)₄]⁸⁺-type macrocyclic complexes for fluorescent sensing of HSO₃^-. Chinese Journal of Inorganic Chemistry, 2024, 40(7): 1233-1242. doi: 10.11862/CJIC.20240057
6. [6]
  Yanting HUANG , Hua XIANG , Mei PAN . Construction and application of multi-component systems based on luminous copper nanoclusters. Chinese Journal of Inorganic Chemistry, 2024, 40(11): 2075-2090. doi: 10.11862/CJIC.20240196
7. [7]
  Luyao Lu , Chen Zhu , Fei Li , Pu Wang , Xi Kang , Yong Pei , Manzhou Zhu . Ligand effects on geometric structures and catalytic activities of atomically precise copper nanoclusters. Chinese Journal of Structural Chemistry, 2024, 43(10): 100411-100411. doi: 10.1016/j.cjsc.2024.100411
8. [8]
  Rui Su , Xiaowei Fang , Peng Zeng , Yong Qian , Xuanzhu Li , Huiyu Xing , Jiamei Lin , Jiaquan Xu . Mass spectrometry for non-destructive detection of the average diameter of micro copper wires. Chinese Chemical Letters, 2025, 36(10): 110748-. doi: 10.1016/j.cclet.2024.110748
9. [9]
  Zhiqiang Liu , Qiang Gao , Wei Shen , Meifeng Xu , Yunxin Li , Weilin Hou , Hai-Wei Shi , Yaozuo Yuan , Erwin Adams , Hian Kee Lee , Sheng Tang . Removal and fluorescence detection of antibiotics from wastewater by layered double oxides/metal-organic frameworks with different topological configurations. Chinese Chemical Letters, 2024, 35(8): 109338-. doi: 10.1016/j.cclet.2023.109338
10. [10]
  Jia-Li Xie , Tian-Jin Xie , Yu-Jie Luo , Kai Mao , Cheng-Zhi Huang , Yuan-Fang Li , Shu-Jun Zhen . Octopus-like DNA nanostructure coupled with graphene oxide enhanced fluorescence anisotropy for hepatitis B virus DNA detection. Chinese Chemical Letters, 2024, 35(6): 109137-. doi: 10.1016/j.cclet.2023.109137
11. [11]
  Meirong HAN , Xiaoyang WEI , Sisi FENG , Yuting BAI . A zinc-based metal-organic framework for fluorescence detection of trace Cu²⁺. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1603-1614. doi: 10.11862/CJIC.20240150
12. [12]
  Gaojian Yang , Zhiyang Li , Rabia Usman , Zhu Chen , Yuan Liu , Song Li , Hui Chen , Yan Deng , Yile Fang , Nongyue He . DNA walker induced "signal on" fluorescence aptasensor strategy for rapid and sensitive detection of extracellular vesicles in gastric cancer. Chinese Chemical Letters, 2025, 36(2): 109930-. doi: 10.1016/j.cclet.2024.109930
13. [13]
  Shu Tian , Wenxin Huang , Junrui Hu , Huiling Wang , Zhipeng Zhang , Liying Xu , Junrong Li , Yao Sun . Exploring the frontiers of plant health: Harnessing NIR fluorescence and surface-enhanced Raman scattering modalities for innovative detection. Chinese Chemical Letters, 2025, 36(3): 110336-. doi: 10.1016/j.cclet.2024.110336
14. [14]
  Ren Shen , Yanmei Fang , Chunxiao Yang , Quande Wei , Pui-In Mak , Rui P. Martins , Yanwei Jia . UV-assisted ratiometric fluorescence sensor for one-pot visual detection of Salmonella. Chinese Chemical Letters, 2025, 36(4): 110143-. doi: 10.1016/j.cclet.2024.110143
15. [15]
  Shuyun Li , Taoyang Wang , Yajing Zhang , Wenqi Wei , Qiuping Xie , Yiran Pu , Gonghua Hong , Xiaoling Wang , Yunxiang He , Junling Guo . Tuning fluorescence of polyphenol-based carbon dots for tetracycline and quinolone selective detection. Chinese Chemical Letters, 2026, 37(5): 111356-. doi: 10.1016/j.cclet.2025.111356
16. [16]
  Zhifeng CAI , Yiran ZHANG , Qun CAI , Miao JIA , Yaxuan FENG , Yuqi ZHANG . Ratiometric fluorescent probes based on nitrogen-doped carbon dots for the fluorescence detection of sulfide ions. Chinese Journal of Inorganic Chemistry, 2026, 42(5): 1015-1025. doi: 10.11862/CJIC.20250366
17. [17]
  He Yao , Wenhao Ji , Yi Feng , Chunbo Qian , Chengguang Yue , Yue Wang , Shouying Huang , Mei-Yan Wang , Xinbin Ma . Copper-catalyzed and biphosphine ligand controlled 3,4-boracarboxylation of 1,3-dienes with carbon dioxide. Chinese Chemical Letters, 2025, 36(4): 110076-. doi: 10.1016/j.cclet.2024.110076
18. [18]
  Hao Liu , Kang Li , Fengyi Li , Yan Zhao , Weigang Fan , Yong Pei , Man-Bo Li . Cobalt-kernelled icosahedral gold nanocluster. Chinese Chemical Letters, 2026, 37(8): 111230-. doi: 10.1016/j.cclet.2025.111230
19. [19]
  Xianxin Luo , Jianhao Xu , Qi Luo , Yan Xiao , Feng Wei , Meitong Li , Wenjiao Yuan , Penghui Shao , Shenglian Luo . Efficient copper sorption from saline wastewater using citrate-modified biochar with robust anti-salt interferences. Chinese Chemical Letters, 2026, 37(5): 111914-. doi: 10.1016/j.cclet.2025.111914
20. [20]
  Tiancong Shi , Xi Chen , Xiao Zhou , Hongyi Zhang , Fuping Han , Lihan Cai , Wen Sun , Jianjun Du , Jiangli Fan , Xiaojun Peng . Azaindole-based asymmetric pentamethine cyanine dye for mitochondrial pH detection and near-infrared ratiometric fluorescence imaging of mitophagy. Chinese Chemical Letters, 2025, 36(6): 110408-. doi: 10.1016/j.cclet.2024.110408

Get Citation

PDF

XML

Metrics

PDF Downloads(10)
Abstract views(1864)
HTML views(218)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142