Citation: Rui WU, Yankun ZHANG, Jiufu LU, Pengfei ZHANG, Yang WANG. Research process on radioactive ¹⁸F-labelled chemical agents as positron emission tomography imaging probes for tumour detection[J]. Chinese Journal of Inorganic Chemistry, ;2025, 41(9): 1702-1718. doi: 10.11862/CJIC.20240387 shu

Research process on radioactive ¹⁸F-labelled chemical agents as positron emission tomography imaging probes for tumour detection

Rui WU ^1,, ,
Yankun ZHANG ² ,
Jiufu LU ¹ ,
Pengfei ZHANG ^3,, ,
Yang WANG ⁴

1.
Shaanxi Key Laboratory of Catalysis, College of Chemical & Environmental Science, Shaanxi University of Technology, Hanzhong, Shaanxi 723001, China
2.
People′s Hospital of Hanzhong, Hanzhong, Shaanxi 723001, China
3.
School of Textile Science and Engineering, Xi′an Polytechnic University, Xi′an 710048, China
4.
Hanzhong Center Hospital, Hanzhong, Shaanxi 723001, China

Corresponding author: Rui WU, wurui@snut.edu.cn Pengfei ZHANG, hftffc@163.com
Received Date: 28 October 2024
Revised Date: 5 July 2025

Figures(6)

Malignant tumours always threaten human health. For tumour diagnosis, positron emission tomography (PET) is the most sensitive and advanced imaging technique by radiotracers, such as radioactive ¹⁸F, ¹¹C, ⁶⁴Cu, ⁶⁸Ga, and ⁸⁹Zr. Among the radiotracers, the radioactive ¹⁸F-labelled chemical agent as PET probes plays a predominant role in monitoring, detecting, treating, and predicting tumours due to its perfect half-life. In this paper, the ¹⁸F-labelled chemical materials as PET probes are systematically summarized. First, we introduce various radionuclides of PET and elaborate on the mechanism of PET imaging. It highlights the ¹⁸F-labelled chemical agents used as PET probes, including [¹⁸F]-2-deoxy-2-[¹⁸F]fluoro-D-glucose ([¹⁸F]-FDG), ¹⁸F-labelled amino acids, ¹⁸F-labelled nucleic acids, ¹⁸F-labelled receptors, 18F-labelled reporter genes, and ¹⁸F-labelled hypoxia agents. In addition, some PET probes with metal as a supplementary element are introduced briefly. Meanwhile, the ¹⁸F-labelled nanoparticles for the PET probe and the multi-modality imaging probe are summarized in detail. The approach and strategies for the fabrication of ¹⁸F-labelled PET probes are also described briefly. The future development of the PET probe is also prospected. The development and application of ¹⁸F-labelled PET probes will expand our knowledge and shed light on the diagnosis and theranostics of tumours.
- ¹⁸F,
- radioactive,
- imaging,
- positron emission tomography,
- labelled,
- tumour
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Research process on radioactive 18F-labelled chemical agents as positron emission tomography imaging probes for tumour detection

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Research process on radioactive ¹⁸F-labelled chemical agents as positron emission tomography imaging probes for tumour detection