Citation: Di WU, Ruimeng SHI, Zhaoyang WANG, Yuehua SHI, Fan YANG, Leyong ZENG. Construction of pH/photothermal dual-responsive delivery nanosystem for combination therapy of drug-resistant bladder cancer cell[J]. Chinese Journal of Inorganic Chemistry, ;2024, 40(9): 1679-1688. doi: 10.11862/CJIC.20240135 shu

Construction of pH/photothermal dual-responsive delivery nanosystem for combination therapy of drug-resistant bladder cancer cell

Di WU ¹ ,
Ruimeng SHI ² ,
Zhaoyang WANG ¹ ,
Yuehua SHI ¹ ,
Fan YANG ^3,, ,
Leyong ZENG ^1,,

1.
Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Chemical Biology Key Laboratory of Hebei Province, College of Chemistry & Materials Science, Hebei University, Baoding, Hebei 071000, China
2.
College of Basic Medical Sciences, Hebei University, Baoding, Hebei 071000, China
3.
Department of Urology, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, China

Corresponding author: Fan YANG, yangfan19862014@163.com Leyong ZENG, zengly@hbu.cn
Received Date: 18 April 2024
Revised Date: 25 June 2024

Figures(7)

Mesoporous nanomaterials showed potential application in drug delivery, but non-specific leakage and multi-drug resistance seriously restricted the efficacy of chemotherapy. Based on the synthesis of mesoporous poly-dopamine (MPDA), pH/photothermal dual-responsive MPDA-DOX@PCM delivery nanosystem was constructed by loading chemotherapy drug doxorubicin (DOX) and coating phase-change material (PCM) 1-tetradecanol, by which the photothermal therapy (PTT) and chemotherapy were achieved towards drug-resistant bladder cancer cell (BIU-87/ADR). The results indicated that the size of MPDA-DOX@PCM was about 179 nm, the max loading rate of DOX was 22%, and the photothermal conversion efficiency was up to 49.1%. Under the conditions of pH=7.4 and 25 ℃, the accumulative release rate of DOX was 4.57%, but can increase to 60.13% with the conditions of pH=5.5 and 45 ℃. Under the irradiation of 808 nm laser, the viability of BIU-87/ADR cells incubated with MPDA-DOX@PCM decreased to 9.5%, demonstrating the excellent combination performance of PTT/chemotherapy.
- mesoporous polydopamine,
- drug delivery,
- dual-response,
- combination therapy,
- bladder cancer cell
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