Citation: Tao LIU, Yuting TIAN, Ke GAO, Xuwei HAN, Ru'nan MIN, Wenjing ZHAO, Xueyi SUN, Caixia YIN. A photothermal agent with high photothermal conversion efficiency and high stability for tumor therapy[J]. Chinese Journal of Inorganic Chemistry, ;2024, 40(8): 1622-1632. doi: 10.11862/CJIC.20240107 shu

A photothermal agent with high photothermal conversion efficiency and high stability for tumor therapy

Tao LIU ^1,, ,
Yuting TIAN ^{1, 3} ,
Ke GAO ^{1, 3} ,
Xuwei HAN ^{1, 3} ,
Ru'nan MIN ^{1, 3} ,
Wenjing ZHAO ¹ ,
Xueyi SUN ¹ ,
Caixia YIN ^2,,

1.
Department of Chemical and Material Engineering, Lyuliang University, Lüliang, Shanxi 033001, China
2.
Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Molecular Science, Shanxi University, Taiyuan 030006, China
3.
School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China

Corresponding author: Tao LIU, liutao@llu.edu.cn Caixia YIN, yincx@sxu.edu.cn
Received Date: 2 April 2024
Revised Date: 11 July 2024

Figures(8)

A photothermal agent (ECEI) with high photothermal conversion efficiency (85.78%) was synthesized based on coumarin fluorescent groups. In addition, the experimental results of hot and cold cycling show that ECEI has good photostability. Despite damage to the mitochondrial membrane potential, ECEI can effectively target mitochondria and induce cancer cell death under laser irradiation. This allows ECEI to maximize mitochondrial damage and thus inhibit tumor cell reproduction. Notable, after irradiating mouse tumors once, the mouse tumors gradually disappeared within 10 d. This indicates that ECEI has an excellent tumor inhibition effect.
- photothermal therapy,
- tumor ablation,
- high photothermal conversion efficiency
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