Citation: Jingjing QING, Fan HE, Zhihui LIU, Shuaipeng HOU, Ya LIU, Yifan JIANG, Mengting TAN, Lifang HE, Fuxing ZHANG, Xiaoming ZHU. Synthesis, structure, and anticancer activity of two complexes of dimethylglyoxime organotin[J]. Chinese Journal of Inorganic Chemistry, ;2024, 40(7): 1301-1308. doi: 10.11862/CJIC.20240003 shu

Synthesis, structure, and anticancer activity of two complexes of dimethylglyoxime organotin

Hunan Provincial Key Laboratory of Functional Metal-Organic Compounds, Key Laboratory of Organometallic New Materials, College of Hunan Province, Hunan Engineering Research Center for Monitoring and Treatment of Heavy Metals Pollution in the Upper Reaches of Xiangjiang River, Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China

Corresponding author: Fuxing ZHANG, zfx8056@163.com
Received Date: 3 January 2024
Revised Date: 1 February 2024

Figures(5)

Two dimethylglyoxime organotin compounds, bis(tri(2-methyl-2-phenylpropyl)tin) dimethylglyoxime complex (C₆H₅C(CH₃)₂CH₂)₃Sn(ON=C(CH₃)C(CH₃) =NO)Sn(CH₂C(CH₃)₂C₆H₅)₃ (1) and di(benzyl)tin oxide, chlorine, butanedione oxime multinuclear complex [μ₃-O-((C₆H₅CH₂)₂Sn)₂(ON=C(CH₃)C(CH₃)=NOH)(O)Cl]₂ (2), were synthesized. The compounds were characterized by elemental analysis, IR spectroscopy, NMR (¹H, ¹³C, and ¹¹⁹Sn), thermogravimetric analysis, and single-crystal X-ray diffraction, and quantum chemical ab initio calculation was performed for their structure and in vitro anticancer activity were studied for the compounds. The results showed that complex 1 is a central symmetric molecule with double tin nuclei bridged by the ligand dimethylglyoxime, and the tin atoms are distorted tetrahedral configurations with four coordination. Complex 2 is a central symmetric polycyclic polymerization structure of tetratin nuclei bridged by oxygen atoms and dimethylglyoxime, and the tin atoms are five-coordinated distorted triangular bipyramidal configuration and six-coordinated distorted octahedral configuration, respectively. In addition, the complexes have stronger inhibitory activity on human liver cancer cells(HUH7), human lung cancer cells (A549), human epidermal cancer cells (A431), human colon cancer cells (HCT-116), and breast cancer cells (MDA-MB-231).
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