Citation: Botao QU, Qian WANG, Xiaogang NING, Yuxin ZHOU, Ruiping ZHANG. Deeply penetrating photoacoustic imaging in tumor tissues based on dual-targeted melanin nanoparticle[J]. Chinese Journal of Inorganic Chemistry, ;2024, 40(5): 1025-1032. doi: 10.11862/CJIC.20230416 shu

Deeply penetrating photoacoustic imaging in tumor tissues based on dual-targeted melanin nanoparticle

Botao QU ^{1, #} ,
Qian WANG ^{2, #} ,
Xiaogang NING ^{3, #} ,
Yuxin ZHOU ¹ ,
Ruiping ZHANG ^4,,

1.
School of Basic Medical Sciences, Shanxi Medical University, Taiyuan 030001, China
2.
School of Forensic Medicine, Shanxi Medical University, Taiyuan 030001, China
3.
School of Chinese Medicine and Food Engineering, Shanxi University of Chinese Medicine, Jinzhong, Shanxi 030619, China
4.
The Radiology Department of First Hospital of Shanxi Medical University, Taiyuan 030001, China

Corresponding author: Ruiping ZHANG, beyondthj@163.com; zrp_7142@sxmu.edu.cn
Received Date: 1 November 2023
Revised Date: 6 March 2024

Figures(5)

A dual-targeting melanin nanoparticle (MNP-TPP-HA) was constructed by grafting the carboxyl groups of hyaluronic acid (HA) and (4-carboxybutyl) triphenylphosphonium bromide (TPP) onto the surface of polyethylene glycol-amino (PEG-NH₂) modified MNP based on 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) and N-hydroxy succinimide (NHS) reaction, endowing melanin with the ability of dual active targeting. The fluorescence imaging of in vitro three-dimensional (3D) tumor models and in vivo photoacoustic imaging (PAI) all reveal the excellent target penetration ability of MNP-TPP-HA.
- dual-targeting,
- melanin,
- photoacoustic imaging,
- penetration ability
1. [1]
  Hanahan D, Weinberg R A. Hallmarks of cancer: The next generation[J]. Cell, 2011,144(5):646-674. doi: 10.1016/j.cell.2011.02.013
2. [2]
  Giraldo N A, Sanchez-Salas R, Peske J D, Vano Y, Becht E, Petitprez F, Validire P, Ingels A, Cathelineau X, Fridman W H, Sautès-Fridman C. The clinical role of the TME in solid cancer[J]. Br. J. Cancer, 2019,120(1):45-53. doi: 10.1038/s41416-018-0327-z
3. [3]
  Gong F, Yang N L, Wang X W, Zhao Q, Chen Q, Liu Z, Cheng L. Tumor microenvironment-responsive intelligent nanoplatforms for cancer theranostics[J]. Nano Today, 2020,32100851. doi: 10.1016/j.nantod.2020.100851
4. [4]
  Ortiz R, Quinonero F, Garcia-Pinel B, Fuel M, Mesas C, Cabeza L, Melguizo C, Prados J. Nanomedicine to overcome multidrug resistance mechanisms in colon and pancreatic cancer: Recent progress[J]. Cancers, 2021,13(9)2058. doi: 10.3390/cancers13092058
5. [5]
  Mura S, Couvreur P. Nanotheranostics for personalized medicine[J]. Adv. Drug Deliv. Rev., 2012,64(13):1394-1416. doi: 10.1016/j.addr.2012.06.006
6. [6]
  Overchuk M, Zheng G. Overcoming obstacles in the tumor microenvironment: Recent advancements in nanoparticle delivery for cancer theranostics[J]. Biomaterials, 2018,156:217-237. doi: 10.1016/j.biomaterials.2017.10.024
7. [7]
  Certo M, Tsai C H, Pucino V, Ho P C, Mauro C. Lactate modulation of immune responses in inflammatory versus tumour microenvironments[J]. Nat. Rev. Immunol., 2021,21(3):151-161. doi: 10.1038/s41577-020-0406-2
8. [8]
  Roma-Rodrigues C, Pombo I, Raposo L, Pedrosa P, Fernandes A R, Baptista P V. Nanotheranostics targeting the tumor microenvironment[J]. Front. Bioeng. Biotechnol., 2019,7197. doi: 10.3389/fbioe.2019.00197
9. [9]
  Sikkandhar M G, Nedumaran A M, Ravichandar R, Singh S, Santhakumar I, Goh Z C, Mishra S, Archunan G, Gulyás B, Padmanabhan P. Theranostic probes for targeting tumor microenvironment: An overview[J]. Int. J. Mol. Sci., 2017,18(5)1036. doi: 10.3390/ijms18051036
10. [10]
  d'Ischia M, Napolitano A, Pezzella A, Meredith P, Buehler M. Melanin biopolymers: Tailoring chemical complexity for materials design[J]. Angew. Chem. Int. Ed., 2020,59(28):11196-11205. doi: 10.1002/anie.201914276
11. [11]
  Qi C, Fu L H, Xu H, Wang T F, Lin J, Huang P. Melanin/polydopamine-based nanomaterials for biomedical applications[J]. Sci. China-Chem., 2019,62(2):162-188. doi: 10.1007/s11426-018-9392-6
12. [12]
  Qu B T, Zhang X M, Han Y H, Peng X Y, Sun J H, Zhang R P. IR820 functionalized melanin nanoplates for dual-modal imaging and photothermal tumor eradication[J]. Nanoscale Adv., 2020,2(6):2587-2594. doi: 10.1039/D0NA00236D
13. [13]
  Caldas M, Santos A C, Veiga F, Rebelo R, Reis R L, Correlo V M. Melanin nanoparticles as a promising tool for biomedical applications-a review[J]. Acta Biomater., 2020,105:26-43. doi: 10.1016/j.actbio.2020.01.044
14. [14]
  Longo D L, Stefania R, Aime S, Oraevsky A. Melanin-based contrast agents for biomedical optoacoustic imaging and theranostic applications[J]. Int. J. Mol. Sci., 2017,18(8)1719. doi: 10.3390/ijms18081719
15. [15]
  Liu Y L, Ai K L, Ji X Y, Askhatova D, Du R, Lu L H, Shi J J. Comprehensive insights into the multi-antioxidative mechanisms of melanin nanoparticles and their application to protect brain from injury in ischemic stroke[J]. J. Am. Chem. Soc., 2017,139(2):856-862. doi: 10.1021/jacs.6b11013
16. [16]
  Bayer I S. Hyaluronic acid and controlled release: A review[J]. Molecules, 2020,25(11)2649. doi: 10.3390/molecules25112649
17. [17]
  Lei C, Liu X R, Chen Q B, Li Y, Zhou J L, Zhou L Y, Zou T. Hyaluronic acid and albumin based nanoparticles for drug delivery[J]. J. Control. Release, 2021,331:416-433. doi: 10.1016/j.jconrel.2021.01.033
18. [18]
  Cheng X X, Feng D, Lv J Y, Cui X M, Wang Y C, Wang Q, Zhang L. Application prospects of triphenylphosphine-based mitochondria- targeted cancer therapy[J]. Cancers, 2023,15(3)666. doi: 10.3390/cancers15030666
19. [19]
  Gong N Q, Ma X W, Ye X X, Zhou Q F, Chen X A, Tan X L, Yao S K, Huo S D, Zhang T B, Chen S Z, Teng X C, Hu X X, Yu J, Gan Y L, Jiang H D, Li J H, Liang X J. Carbon-dot-supported atomically dispersed gold as a mitochondrial oxidative stress amplifier for cancer treatment[J]. Nat. Nanotechnol., 2019,14(4):379-387. doi: 10.1038/s41565-019-0373-6
20. [20]
  Mattheolabakis G, Milane L, Singh A, Amiji M M. Hyaluronic acid targeting of CD44 for cancer therapy: From receptor biology to nanomedicine[J]. J. Drug Target., 2015,23(7/8):605-618.
21. [21]
  Feng G X, Qin W, Hu Q L, Tang B Z, Liu B. Cellular and mitochondrial dual-targeted organic dots with aggregation-induced emission characteristics for image-guided photodynamic therapy[J]. Adv. Healthc. Mater., 2015,4(17):2667-2676. doi: 10.1002/adhm.201500431
22. [22]
  Luo Z J, Dai Y, Gao H L. Development and application of hyaluronic acid in tumor targeting drug delivery[J]. Acta Pharm. Sin. B, 2019,9(6):1099-1112. doi: 10.1016/j.apsb.2019.06.004
23. [23]
  Tripodo G, Trapani A, Torre M L, Giammona G, Trapani G, Mandracchia D. Hyaluronic acid and its derivatives in drug delivery and imaging: Recent advances and challenges[J]. Eur. J. Pharm. Biopharm., 2015,97(Part B):400-416.
24. [24]
  Ashrafizadeh M, Mirzaei S, Gholami M H, Hashemi F, Zabolian A, Raei M, Hushmandi K, Zarrabi A, Voelcker N H, Aref A R, Hamblin M R, Varma R S, Samarghandian S, Arostegi I J, Alzola M, Kumar A P, Thakur V K, Nabavi N, Makvandi P, Tay F R, Orive G. Hyaluronic acid-based nanoplatforms for Doxorubicin: A review of stimuli‐responsive carriers, co-delivery and resistance suppression[J]. Carbohydr. Polym., 2021,272118491. doi: 10.1016/j.carbpol.2021.118491
25. [25]
  Hu Q L, Gao M, Feng G X, Liu B. Mitochondria-targeted cancer therapy using a light-up probe with aggregation-induced-emission characteristics[J]. Angew. Chem. Int. Ed., 2014,53(51):14225-14229. doi: 10.1002/anie.201408897
26. [26]
  Li F, Liu Y J, Dong Y H, Chu Y W, Song N C, Yang D Y. Dynamic assembly of DNA nanostructures in living cells for mitochondrial interference[J]. J. Am. Chem. Soc., 2022,144(10):4667-4677. doi: 10.1021/jacs.2c00823
27. [27]
  Chang X W, Tang X Y, Liu J, Zhu Z R, Mu W Y, Tang W J, Zhang Y M, Chen X. Precise starving therapy via physiologically dependent photothermal conversion promoted mitochondrial calcification based on multi‐functional gold nanoparticles for effective tumor treatment[J]. Adv. Funct. Mater., 2023,33(35)2303596. doi: 10.1002/adfm.202303596
28. [28]
  ZHANG C L, ZHANG J J, SHEN Y, LU J C, HUANG F, XU L. A rapid response of mitochondrial targeted fluorescent probe for detecting living cells and hypochlorite in zebrafish[J]. Chinese J. Inorg. Chem., 2022,38(8):1623-1632.
29. [29]
  Zhang R P, Fan Q L, Yang M, Cheng K, Lu X M, Zhang L, Huang W, Cheng Z. Engineering melanin nanoparticles as an efficient drug-delivery system for imaging-guided chemotherapy[J]. Adv. Mater., 2015,27(34):5063-5069. doi: 10.1002/adma.201502201
30. [30]
  Pieper J S, Hafmans T, Veerkamp J H, van Kuppevelt T H. Development of tailor-made collagen-glycosaminoglycan matrices: EDC/NHS crosslinking, and ultrastructural aspects[J]. Biomaterials, 2000,21(6):581-593. doi: 10.1016/S0142-9612(99)00222-7
31. [31]
  Li Q Q, Liu L T, Huo H Q, Su L C, Wu Y, Lin H X, Ge X G, Mu J, Zhang X, Zheng L T, Song J B. Nanosized Janus AuNR-Pt motor for enhancing NIR-II photoacoustic imaging of deep tumor and Pt²⁺ ion-based chemotherapy[J]. ACS Nano, 2022,16(5):7947-7960. doi: 10.1021/acsnano.2c00732
32. [32]
  ZHANG P G, YU D C, CHENG Z W, HE Z P, ZHANG X H, LI H L, ZHANG H Q. Application of folate receptor-targeted CdS quantum dots in imaging of HepG2 cells[J]. Chinese J. Inorg. Chem., 2007,23(9):1662-1666. doi: 10.3321/j.issn:1001-4861.2007.09.031
1. [1]
  Jinyu Guo , Yandai Lin , Shaohua He , Yueqing Chen , Fenglu Li , Renjie Ruan , Gaoxing Pan , Hexin Nan , Jibin Song , Jin Zhang . Utilizing dual-responsive iridium(Ⅲ) complex for hepatocellular carcinoma: Integrating photoacoustic imaging with chemotherapy and photodynamic therapy. Chinese Chemical Letters, 2024, 35(9): 109537-. doi: 10.1016/j.cclet.2024.109537
2. [2]
  Ling-Ling Wu , Xiangchuan Meng , Qingyang Zhang , Xiaowan Han , Feiya Yang , Qinghua Wang , Hai-Yu Hu , Nianzeng Xing . Heavy-atom engineered hypoxia-responsive probes for precisive photoacoustic imaging and cancer therapy. Chinese Chemical Letters, 2024, 35(4): 108663-. doi: 10.1016/j.cclet.2023.108663
3. [3]
  Leichen Wang , Anqing Mei , Na Li , Xiaohong Ruan , Xu Sun , Yu Cai , Jinjun Shao , Xiaochen Dong . Aza-BODIPY dye with unexpected bromination and high singlet oxygen quantum yield for photoacoustic imaging-guided synergetic photodynamic/photothermal therapy. Chinese Chemical Letters, 2024, 35(6): 108974-. doi: 10.1016/j.cclet.2023.108974
4. [4]
  Xuejian Xing , Pan Zhu , E Pang , Shaojing Zhao , Yu Tang , Zheyu Hu , Quchang Ouyang , Minhuan Lan . D-A-D-structured boron-dipyrromethene with aggregation-induced enhanced phototherapeutic efficiency for near-infrared fluorescent and photoacoustic imaging-guided synergistic photodynamic and photothermal cancer therapy. Chinese Chemical Letters, 2024, 35(10): 109452-. doi: 10.1016/j.cclet.2023.109452
5. [5]
  Zihong Li , Jie Cheng , Ping Huang , Guoliang Wu , Weiying Lin . Activatable photoacoustic bioprobe for visual detection of aging in vivo. Chinese Chemical Letters, 2024, 35(4): 109153-. doi: 10.1016/j.cclet.2023.109153
6. [6]
  Jing Wang , Zenghui Li , Xiaoyang Liu , Bochao Su , Honghong Gong , Chao Feng , Guoping Li , Gang He , Bin Rao . Fine-tuning redox ability of arylene-bridged bis(benzimidazolium) for electrochromism and visible-light photocatalysis. Chinese Chemical Letters, 2024, 35(9): 109473-. doi: 10.1016/j.cclet.2023.109473
7. [7]
  Yi Cao , Xiaojiao Ge , Yuanyuan Wei , Lulu He , Aiguo Wu , Juan Li . Tumor microenvironment-activatable neuropeptide-drug conjugates enhanced tumor penetration and inhibition via multiple delivery pathways and calcium deposition. Chinese Chemical Letters, 2024, 35(4): 108672-. doi: 10.1016/j.cclet.2023.108672
8. [8]
  Lishan Xiong , Xinyuan Li , Xiaojie Lu , Zhendong Zhang , Yan Zhang , Wen Wu , Chenhui Wang . Inhaled multilevel size-tunable, charge-reversible and mucus-traversing composite microspheres as trojan horse: Enhancing lung deposition and tumor penetration. Chinese Chemical Letters, 2024, 35(9): 109384-. doi: 10.1016/j.cclet.2023.109384
9. [9]
  Han Han , Bi-Te Chen , Jia-Rong Ding , Jin-Ming Si , Tian-Jiao Zhou , Yi Wang , Lei Xing , Hu-Lin Jiang . A PDGFRβ-targeting nanodrill system for pancreatic fibrosis therapy. Chinese Chemical Letters, 2024, 35(10): 109583-. doi: 10.1016/j.cclet.2024.109583
10. [10]
  Jing-Jing Zhang , Lujun Lou , Rui Lv , Jiahui Chen , Yinlong Li , Guangwei Wu , Lingchao Cai , Steven H. Liang , Zhen Chen . Recent advances in photochemistry for positron emission tomography imaging. Chinese Chemical Letters, 2024, 35(8): 109342-. doi: 10.1016/j.cclet.2023.109342
11. [11]
  Shihong Wu , Ronghui Zhou , Hang Zhao , Peng Wu . Sonoafterglow luminescence for in vivo deep-tissue imaging. Chinese Chemical Letters, 2024, 35(10): 110026-. doi: 10.1016/j.cclet.2024.110026
12. [12]
  Xiaohong Wen , Mei Yang , Lie Li , Mingmin Huang , Wei Cui , Suping Li , Haiyan Chen , Chen Li , Qiuping Guo . Enzymatically controlled DNA tetrahedron nanoprobes for specific imaging of ATP in tumor. Chinese Chemical Letters, 2024, 35(8): 109291-. doi: 10.1016/j.cclet.2023.109291
13. [13]
  Gongcheng Ma , Qihang Ding , Yuding Zhang , Yue Wang , Jingjing Xiang , Mingle Li , Qi Zhao , Saipeng Huang , Ping Gong , Jong Seung Kim . Palladium-free chemoselective probe for in vivo fluorescence imaging of carbon monoxide. Chinese Chemical Letters, 2024, 35(9): 109293-. doi: 10.1016/j.cclet.2023.109293
14. [14]
  Qiang Li , Jiangbo Fan , Hongkai Mu , Lin Chen , Yongzhen Yang , Shiping Yu . Nucleus-targeting orange-emissive carbon dots delivery adriamycin for enhanced anti-liver cancer therapy. Chinese Chemical Letters, 2024, 35(6): 108947-. doi: 10.1016/j.cclet.2023.108947
15. [15]
  Weijian Zhang , Xianyu Deng , Liying Wang , Jian Wang , Xiuting Guo , Lianggui Huang , Xinyi Wang , Jun Wu , Linjia Jiang . Poly(ferulic acid) nanocarrier enhances chemotherapy sensitivity of acute myeloid leukemia by selectively targeting inflammatory macrophages. Chinese Chemical Letters, 2024, 35(9): 109422-. doi: 10.1016/j.cclet.2023.109422
16. [16]
  Peng Jia , Yunna Guo , Dongliang Chen , Xuedong Zhang , Jingming Yao , Jianguo Lu , Liqiang Zhang . In-situ imaging electrocatalysis in a solid-state Li-O₂ battery with CuSe nanosheets as air cathode. Chinese Chemical Letters, 2024, 35(5): 108624-. doi: 10.1016/j.cclet.2023.108624
17. [17]
  Boran Cheng , Lei Cao , Chen Li , Fang-Yi Huo , Qian-Fang Meng , Ganglin Tong , Xuan Wu , Lin-Lin Bu , Lang Rao , Shubin Wang . Fluorine-doped carbon quantum dots with deep-red emission for hypochlorite determination and cancer cell imaging. Chinese Chemical Letters, 2024, 35(6): 108969-. doi: 10.1016/j.cclet.2023.108969
18. [18]
  Hui-Juan Wang , Wen-Wen Xing , Zhen-Hai Yu , Yong-Xue Li , Heng-Yi Zhang , Qilin Yu , Hongjie Zhu , Yao-Yao Wang , Yu Liu . Cucurbit[7]uril confined phenothiazine bridged bis(bromophenyl pyridine) activated NIR luminescence for lysosome imaging. Chinese Chemical Letters, 2024, 35(6): 109183-. doi: 10.1016/j.cclet.2023.109183
19. [19]
  Jingqi Xin , Shupeng Han , Meichen Zheng , Chenfeng Xu , Zhongxi Huang , Bin Wang , Changmin Yu , Feifei An , Yu Ren . A nitroreductase-responsive nanoprobe with homogeneous composition and high loading for preoperative non-invasive tumor imaging and intraoperative guidance. Chinese Chemical Letters, 2024, 35(7): 109165-. doi: 10.1016/j.cclet.2023.109165
20. [20]
  Yiling Li , Zekun Gao , Xiuxiu Yue , Minhuan Lan , Xiuli Zheng , Benhua Wang , Shuang Zhao , Xiangzhi Song . FRET-based two-photon benzo[a] phenothiazinium photosensitizer for fluorescence imaging-guided photodynamic therapy. Chinese Chemical Letters, 2024, 35(7): 109133-. doi: 10.1016/j.cclet.2023.109133

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(93)
HTML views(9)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142