Citation: Botao QU, Qian WANG, Xiaogang NING, Yuxin ZHOU, Ruiping ZHANG. Deeply penetrating photoacoustic imaging in tumor tissues based on dual-targeted melanin nanoparticle[J]. Chinese Journal of Inorganic Chemistry, ;2024, 40(5): 1025-1032. doi: 10.11862/CJIC.20230416 shu

Deeply penetrating photoacoustic imaging in tumor tissues based on dual-targeted melanin nanoparticle

Botao QU ^{1, #} ,
Qian WANG ^{2, #} ,
Xiaogang NING ^{3, #} ,
Yuxin ZHOU ¹ ,
Ruiping ZHANG ^4,,

1.
School of Basic Medical Sciences, Shanxi Medical University, Taiyuan 030001, China
2.
School of Forensic Medicine, Shanxi Medical University, Taiyuan 030001, China
3.
School of Chinese Medicine and Food Engineering, Shanxi University of Chinese Medicine, Jinzhong, Shanxi 030619, China
4.
The Radiology Department of First Hospital of Shanxi Medical University, Taiyuan 030001, China

Corresponding author: Ruiping ZHANG, beyondthj@163.com; zrp_7142@sxmu.edu.cn
Received Date: 1 November 2023
Revised Date: 6 March 2024

Figures(5)

A dual-targeting melanin nanoparticle (MNP-TPP-HA) was constructed by grafting the carboxyl groups of hyaluronic acid (HA) and (4-carboxybutyl) triphenylphosphonium bromide (TPP) onto the surface of polyethylene glycol-amino (PEG-NH₂) modified MNP based on 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) and N-hydroxy succinimide (NHS) reaction, endowing melanin with the ability of dual active targeting. The fluorescence imaging of in vitro three-dimensional (3D) tumor models and in vivo photoacoustic imaging (PAI) all reveal the excellent target penetration ability of MNP-TPP-HA.
- dual-targeting,
- melanin,
- photoacoustic imaging,
- penetration ability
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