Citation: Xin DENG, Fu-Xing ZHANG, Jing-Jing QING, Ge YANG, Fan HE, Li-Fang HE, Zhi-Hui LIU, Shuai-Peng HOU. Synthesis, structure, and anticancer activity of two benzohydroxamic acid organotin complexes[J]. Chinese Journal of Inorganic Chemistry, ;2023, 39(11): 2083-2090. doi: 10.11862/CJIC.2023.182 shu

Synthesis, structure, and anticancer activity of two benzohydroxamic acid organotin complexes

Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Organometallic New Materials, University of Hunan Province, Hunan Engineering Research Center for Monitoring and Treatment of Heavy Metals Pollution in the Upper Reaches of Xiangjiang River, Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China

Corresponding author: Fu-Xing ZHANG, zfx8056@163.com
Received Date: 23 May 2023
Revised Date: 27 September 2023

Figures(5)

Two benzohydroxamic acid organotin complexes[(o-Cl-C₆H₄CH₂)₂Sn(C₆H₅CONO)₂] (1) and[(o-CH₃-C₆H₄CH₂)₂Sn(C₆H₅CONO) (C₆H₅COO)] (2) were synthesized by solvothermal method using methanol as a solvent. Complexes 1 and 2 were characterized by elemental analysis, IR, ¹H NMR, thermogravimetric analysis, single-crystal X-ray diffraction, etc. The study on the complexes has been performed with quantum chemistry calculation and in vitro anticancer activity. The results show that the two complexes are monotin nuclear structures; complexes 1 and 2 are the six-coordinated distorted octahedron configuration and seven-coordinated distorted triangular bipyramid configuration, respectively. Complex 1 showed stronger inhibitory activity on human cervical cancer cells (HeLa), hepatoma cells (HuH-7), and lung adenocarcinoma cells (H1975) than cisplatin, while complex 2 showed much weaker inhibitory activity.
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